Aquaporin-7

AQP7

Identifiers

AQP7, AQP7L, AQP9, AQPap, GLYCQTL, aquaporin 7

External IDs

OMIM: 602974 MGI: 1314647 HomoloGene: 48000 GeneCards: AQP7

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9p13.3	Start	33,383,179 bp^[1]
Band	9p13.3	End	33,402,682 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 A5	Start	41,033,074 bp^[2]
Band	4\|4 A5	End	41,048,139 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

subcutaneous adipose tissue

left ventricle

sural nerve

gastric mucosa

duodenum

quadriceps femoris muscle

right lobe of liver

kidney

gastrocnemius muscle

skeletal muscle tissue

Top expressed in

spermatid

seminiferous tubule

brown adipose tissue

aortic valve

white adipose tissue

proximal tubule

ascending aorta

sternocleidomastoid muscle

spermatocyte

digastric muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	glycerol channel activity water channel activity channel activity urea transmembrane transporter activity
Cellular component	cytoplasm integral component of membrane plasma membrane integral component of plasma membrane membrane cell-cell junction lipid droplet cell cortex cytoplasmic vesicle membrane cytoplasmic vesicle
Biological process	water transport excretion glycerol transport generation of precursor metabolites and energy transmembrane transport urea transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


364


11832

Ensembl


ENSG00000165269


ENSMUSG00000028427

UniProt


O14520


O54794

RefSeq (mRNA)

NM_001170 NM_001318156 NM_001318157 NM_001318158 NM_001376191
NM_001376192 NM_001376193


NM_007473

RefSeq (protein)

NP_001161 NP_001305085 NP_001305086 NP_001305087 NP_001363120
NP_001363121 NP_001363122

NP_031499 NP_001365567 NP_001365568 NP_001365569 NP_001365570
NP_001365571

Location (UCSC)

Chr 9: 33.38 – 33.4 Mb

Chr 4: 41.03 – 41.05 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene.^[5]^[6]

Aquaporins/major intrinsic proteins (MIP) are a family of water-selective membrane channels. Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin-7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin-7 facilitates water, glycerol and urea transport. It may play an important role in thermoregulation in the form of perspiration, and sperm function.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165269 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028427 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishibashi K, Kuwahara M, Gu Y, Kageyama Y, Tohsaka A, Suzuki F, Marumo F, Sasaki S (Sep 1997). "Cloning and functional expression of a new water channel abundantly expressed in the testis permeable to water, glycerol, and urea". J Biol Chem. 272 (33): 20782–6. doi:10.1074/jbc.272.33.20782. PMID 9252401.
^ ^a ^b "Entrez Gene: AQP7 aquaporin 7".

External links

AQP7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human AQP7 genome location and AQP7 gene details page in the UCSC Genome Browser.
Human AQP9 genome location and AQP9 gene details page in the UCSC Genome Browser.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

This page was last edited on 1 December 2023, at 03:09

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References

Further reading

External links