KCNIP1

KCNIP1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1S1E, 2I2R, 2NZ0

Identifiers

Aliases

KCNIP1, KCHIP1, VABP, potassium voltage-gated channel interacting protein 1

External IDs

OMIM: 604660 MGI: 1917607 HomoloGene: 22824 GeneCards: KCNIP1

Gene location (Human)

Chr.	Chromosome 5 (human)^[1]

Band	5q35.1	Start	170,353,487 bp^[1]
Band	5q35.1	End	170,736,632 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11\|11 A4	Start	33,579,339 bp^[2]
Band	11\|11 A4	End	33,943,152 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

nucleus accumbens

caudate nucleus

amygdala

prefrontal cortex

hypothalamus

putamen

dorsolateral prefrontal cortex

Brodmann area 9

hippocampus proper

islet of Langerhans

Top expressed in

habenula

dorsomedial hypothalamic nucleus

lateral hypothalamus

ventromedial nucleus

superior colliculus

cerebellar vermis

paraventricular nucleus of hypothalamus

islet of Langerhans

ventral tegmental area

arcuate nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	calcium ion binding potassium channel regulator activity potassium channel activity protein binding metal ion binding voltage-gated ion channel activity
Cellular component	cytoplasm extrinsic component of cytoplasmic side of plasma membrane voltage-gated potassium channel complex plasma membrane cell projection dendrite membrane
Biological process	potassium ion transport regulation of ion transmembrane transport ion transport regulation of potassium ion transmembrane transport potassium ion transmembrane transport cardiac conduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


30820


70357

Ensembl


ENSG00000182132


ENSMUSG00000053519

UniProt


Q9NZI2


Q9JJ57

RefSeq (mRNA)


NM_001034837 NM_001034838 NM_001278339 NM_001278340 NM_014592


NM_001190885 NM_001190886 NM_001290690 NM_027398 NM_001363115

RefSeq (protein)


NP_001030009 NP_001030010 NP_001265268 NP_001265269 NP_055407


NP_001177814 NP_001177815 NP_001277619 NP_081674 NP_001350044

Location (UCSC)

Chr 5: 170.35 – 170.74 Mb

Chr 11: 33.58 – 33.94 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

K_v channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.^[5]^[6]

Function

This gene encodes a member of the family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.^[7] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182132 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053519 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–556. Bibcode:2000Natur.403..553A. doi:10.1038/35000592. PMID 10676964. S2CID 4419472.
^ ^a ^b "Entrez Gene: KCNIP1 Kv channel interacting protein 1".
^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

External links

KCNIP1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v t e PDB gallery
1s1e: Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1) 1s6c: Crystal structure of the complex between KChIP1 and Kv4.2 N1-30 2i2r: Crystal structure of the KChIP1/Kv4.3 T1 complex 2nz0: Crystal structure of potassium channel Kv4.3 in complex with its regulatory subunit KChIP1 (CASP Target)

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 17 October 2022, at 09:47

From Wikipedia, the free encyclopedia

Function

See also

References

Further reading

External links