KCNJ14

KCNJ14

Identifiers

KCNJ14, IRK4, KIR2.4, potassium voltage-gated channel subfamily J member 14, potassium inwardly rectifying channel subfamily J member 14

External IDs

OMIM: 603953 MGI: 2384820 HomoloGene: 27086 GeneCards: KCNJ14

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.33	Start	48,455,574 bp^[1]
Band	19q13.33	End	48,466,980 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 B3	Start	45,465,884 bp^[2]
Band	7\|7 B3	End	45,474,206 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

putamen

stromal cell of endometrium

gastrocnemius muscle

skin of abdomen

caudate nucleus

skeletal muscle tissue

prefrontal cortex

bone marrow

ganglionic eminence

cerebellum

Top expressed in

anterior horn of spinal cord

eyelid

olfactory cortex

spinal ganglia

lower eyelid

amygdala

upper eyelid

trigeminal ganglion

septum of telencephalon

autonomic nervous system

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	voltage-gated ion channel activity inward rectifier potassium channel activity
Cellular component	integral component of membrane voltage-gated potassium channel complex neuronal cell body plasma membrane dendrite membrane
Biological process	potassium ion transport regulation of ion transmembrane transport ion transport potassium ion import across plasma membrane cardiac conduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


3770


211480

Ensembl


ENSG00000182324


ENSMUSG00000058743

UniProt


Q9UNX9


Q8JZN3

RefSeq (mRNA)


NM_170720 NM_013348


NM_145963

RefSeq (protein)


NP_037480


NP_666075

Location (UCSC)

Chr 19: 48.46 – 48.47 Mb

Chr 7: 45.47 – 45.47 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), also known as K_ir2.4, is a human gene.^[5]

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. Two transcript variants encoding the same protein have been found for this gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182324 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000058743 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: KCNJ14 potassium inwardly-rectifying channel, subfamily J, member 14".

External links

KCNJ14+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Membrane transport protein: ion channels (TC 1A)

Ca²⁺: Calcium channel

Ligand-gated	Inositol trisphosphate receptor 1 2 3 Ryanodine receptor 1 2 3
Voltage-gated	L-type/Ca_vα 1.1 1.2 1.3 1.4 N-type/Ca_vα2.2 P-type/Ca_vα 2.1 Q-type/Ca_vα2.1 R-type/Ca_vα2.3 T-type/Ca_vα 3.1 3.2 3.3 α₂δ-subunits 1 2 β-subunits β1 β2 β3 β4 γ-subunits γ1 γ2 γ3 γ4 Cation channels of sperm 1 2 3 4 Two-pore channel 1 2

Na⁺: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K⁺: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl⁻: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H⁺: Proton channel	HVCN1
M⁺: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M⁺: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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This page was last edited on 18 August 2023, at 11:35

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See also

References

Further reading

External links