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TB-21007

From Wikipedia, the free encyclopedia

TB-21007
Skeletal formula
Space-filling model
Identifiers
  • 6,6-dimethyl-3-(2-hydroxyethyl)thio-1-(thiazol-2-yl)-6,7-dihydro-2-benzothiophen-4(5H)-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H17NO2S3
Molar mass339.49 g·mol−1
3D model (JSmol)
  • s3ccnc3-c2sc(SCCO)c1c2CC(C)(C)CC1=O
  • InChI=1S/C15H17NO2S3/c1-15(2)7-9-11(10(18)8-15)14(20-6-4-17)21-12(9)13-16-3-5-19-13/h3,5,17H,4,6-8H2,1-2H3 ☒N
  • Key:QILRYFCEXLFIDS-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

TB-21007 is a nootropic drug which acts as a subtype-selective inverse agonist at the α5 containing GABAA receptors.[1][2]

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Transcription

See also

References

  1. ^ Chambers MS, Atack JR, Bromidge FA, Broughton HB, Cook S, Dawson GR, et al. (March 2002). "6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists". Journal of Medicinal Chemistry. 45 (6): 1176–9. doi:10.1021/jm010471b. PMID 11881985.
  2. ^ Chambers MS, Atack JR, Broughton HB, Collinson N, Cook S, Dawson GR, et al. (May 2003). "Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition". Journal of Medicinal Chemistry. 46 (11): 2227–40. doi:10.1021/jm020582q. PMID 12747794.
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This page was last edited on 30 January 2023, at 12:36
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