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CGP-35348

From Wikipedia, the free encyclopedia

CGP-35348
Identifiers
  • 3-Aminopropyl(diethoxymethyl)phosphinic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC8H20NO4P
Molar mass225.225 g·mol−1
3D model (JSmol)
  • CCOC(OCC)P(=O)(CCCN)O
  • InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11) ☒N
  • Key:QIIVUOWTHWIXFO-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

CGP-35348 is a compound used in scientific research which acts as an antagonist at GABAB receptors.[1][2][3]

CGP-35348 was ineffective up to 100 μM to antagonize the inhibitory release of GABA elicited by baclofen, doing so selectively as a GABAB heteroreceptor antagonist. [4] Moreover, CGP-35348 was about threefold less potent in antagonizing gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL) than baclofen and SKF-97,541.[5]

References

  1. ^ Carter LP, Chen W, Coop A, Koek W, France CP (May 2006). "Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348". European Journal of Pharmacology. 538 (1–3): 85–93. doi:10.1016/j.ejphar.2006.03.039. PMID 16647701.
  2. ^ Nasrallah FA, Griffin JL, Balcar VJ, Rae C (August 2007). "Understanding your inhibitions: modulation of brain cortical metabolism by GABA(B) receptors". Journal of Cerebral Blood Flow and Metabolism. 27 (8): 1510–20. doi:10.1038/sj.jcbfm.9600453. PMID 17293844. S2CID 16069846.
  3. ^ Koek W, Mercer SL, Coop A, France CP (September 2009). "Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348)". The Journal of Pharmacology and Experimental Therapeutics. 330 (3): 876–83. doi:10.1124/jpet.109.151845. PMC 2729800. PMID 19564487.
  4. ^ Maurizio Raiteri (2006). "Functional Pharmacology in Human Brain". Pharmacological Reviews. 58 (2): 162–193. doi:10.1124/pr.58.2.5. PMID 16714485. S2CID 14404544.
  5. ^ Koek W1, Mercer SL, Coop A. (June 2007). "Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348". Psychopharmacology. 192 (3): 407–14. doi:10.1007/s00213-007-0718-y. PMID 17277933. S2CID 25049526.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: numeric names: authors list (link)


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This page was last edited on 12 January 2024, at 10:58
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