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Benoxathian

From Wikipedia, the free encyclopedia

Benoxathian
Names
IUPAC name
N-(2,3-Dihydro-1,4-benzoxathiin-2-ylmethyl)-2-(2,6-dimethoxyphenoxy)ethanamine
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C19H23NO4S/c1-21-16-7-5-8-17(22-2)19(16)23-11-10-20-12-14-13-25-18-9-4-3-6-15(18)24-14/h3-9,14,20H,10-13H2,1-2H3
    Key: QAUVAHYHKLRJCQ-UHFFFAOYSA-N
  • InChI=1/C19H23NO4S/c1-21-16-7-5-8-17(22-2)19(16)23-11-10-20-12-14-13-25-18-9-4-3-6-15(18)24-14/h3-9,14,20H,10-13H2,1-2H3
    Key: QAUVAHYHKLRJCQ-UHFFFAOYAX
  • COC1=C(C(=CC=C1)OC)OCCNCC2CSC3=CC=CC=C3O2
Properties
C19H23NO4S
Molar mass 361.46 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Benoxathian is an α1-adrenergic receptor antagonist.[1] It was studied in animals for its antihypertensive (blood pressure lowering) effects in the 1980s.[2]

References

  1. ^ Nagayasu, K; Kitaichi, M; Nishitani, N; Asaoka, N; Shirakawa, H; Nakagawa, T; Kaneko, S (2013). "Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: High potency of milnacipran in the augmentation of serotonin release". The International Journal of Neuropsychopharmacology. 16 (10): 2295–306. doi:10.1017/S1461145713000771. PMID 23920436.
  2. ^ Massi, M.; Venturi, F.; Brasili, L.; Melchiorre, C. (1986). "Hypotensive effect in dogs and rats of intravenous injections of the alpha 1-adrenoreceptor antagonist benoxathian". Pharmacological Research Communications. 18 (9): 813–829. doi:10.1016/0031-6989(86)90132-3. PMID 2879293.



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This page was last edited on 7 January 2022, at 07:19
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