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Bufuralol

From Wikipedia, the free encyclopedia

Bufuralol
Names
Preferred IUPAC name
2-(tert-Butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethan-1-ol
Other names
2-(tert-Butylamino)-1-(7-ethylbenzofuran-2-yl)ethan-1-ol
2-(tert-Butylamino)-1-(7-ethyl-1-benzofuran-2-yl)ethanol
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.053.720 Edit this at Wikidata
UNII
  • InChI=1S/C16H23NO2/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4/h6-9,13,17-18H,5,10H2,1-4H3
  • OC(c2oc1c(cccc1c2)CC)CNC(C)(C)C
Properties
C16H23NO2
Molar mass 261.365 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Bufuralol is a potent beta-adrenoceptor antagonist with partial agonist activity.[1] It is metabolized by CYP2D6.[2]

Most beta blockers are aryloxypropanolamine-based. In this rare exception, the benzofuran oxygen is part of a ring instead of derived from the epichlorohydrin precursor.

References

  1. ^ Pringle, TH; Francis, RJ; East, PB; Shanks, RG (1986). "Pharmacodynamic and pharmacokinetic studies on bufuralol in man". British Journal of Clinical Pharmacology. 22 (5): 527–34. doi:10.1111/j.1365-2125.1986.tb02931.x. PMC 1401192. PMID 2878678.
  2. ^ Flockhart DA (2007). "Drug Interactions: Cytochrome P450 Drug Interaction Table". Indiana University School of Medicine. Retrieved on July 2011
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This page was last edited on 19 August 2019, at 22:49
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