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Primidolol

From Wikipedia, the free encyclopedia

Primidolol
Names
IUPAC name
1-[2-[[2-Hydroxy-3-(2-methylphenoxy)propyl]amino]ethyl]-5-methylpyrimidine-2,4-dione
Identifiers
3D model (JSmol)
ChemSpider
KEGG
UNII
  • InChI=1S/C17H23N3O4/c1-12-5-3-4-6-15(12)24-11-14(21)9-18-7-8-20-10-13(2)16(22)19-17(20)23/h3-6,10,14,18,21H,7-9,11H2,1-2H3,(H,19,22,23)
    Key: RETPFDTUCPKFEC-UHFFFAOYSA-N
  • CC1=CC=CC=C1OCC(CNCCN2C=C(C(=O)NC2=O)C)O
Properties
C17H23N3O4
Molar mass 333.388 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Primidolol is a beta adrenergic receptor antagonist.[1][2][3]

References

  1. ^ Saltvedt, E; Fauchald, P (1980). "Effect of single and twice daily doses of primidolol (UK-11,443) in hypertension". Current Medical Research and Opinion. 6 (8): 528–33. doi:10.1185/03007998009109482. PMID 6104564.
  2. ^ Augstein, J.; Cox, D. A.; Ham, A. L.; Leeming, P. R.; Snarey, M. (1973). "Beta-adrenoceptor blocking agents. 1. Cardioselective 1-aryloxy-3-(aryloxyalkylamino)propan-2-ols". Journal of Medicinal Chemistry. 16 (11): 1245–1251. doi:10.1021/jm00269a007. PMID 4147835.
  3. ^ DE 2238504, Augstein, Joachim; Cox, David Alexander & Ham, Allan Leslie, "Propanolaminderivate [Propanolamine derivates]", published 1973-02-22, assigned to Pfizer Corp. 


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This page was last edited on 16 April 2022, at 15:10
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