Phospholipid transfer protein

PLTP

Identifiers

PLTP, BPIFE, HDLCQ9, phospholipid transfer protein

External IDs

MGI: 103151 HomoloGene: 4536 GeneCards: PLTP

Gene location (Human)

Chr.	Chromosome 20 (human)^[1]

Band	20q13.12	Start	45,898,621 bp^[1]
Band	20q13.12	End	45,912,155 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2 H3\|2 85.27 cM	Start	164,681,438 bp^[2]
Band	2 H3\|2 85.27 cM	End	164,699,631 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right coronary artery

gastric mucosa

gallbladder

body of pancreas

canal of the cervix

left adrenal gland

left coronary artery

thymus

left uterine tube

stromal cell of endometrium

Top expressed in

retinal pigment epithelium

right lung lobe

habenula

molar

left lung

left lung lobe

cerebellar vermis

dorsal tegmental nucleus

paraventricular nucleus of hypothalamus

dorsomedial hypothalamic nucleus

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	lipid binding lipid transporter activity phospholipid transporter activity phosphatidylethanolamine binding phosphatidylcholine transporter activity diacylglycerol binding phosphatidylcholine binding phosphatidic acid binding ceramide binding phosphatidylglycerol binding phosphatidylethanolamine transfer activity phosphatidic acid transfer activity
Cellular component	extracellular region extracellular space high-density lipoprotein particle
Biological process	high-density lipoprotein particle remodeling flagellated sperm motility positive regulation of cholesterol efflux vitamin E biosynthetic process lipid metabolism transport lipid transport phospholipid transport ceramide transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5360


18830

Ensembl


ENSG00000100979


ENSMUSG00000017754

UniProt


P55058


P55065

RefSeq (mRNA)


NM_182676 NM_001242920 NM_001242921 NM_006227


NM_011125

RefSeq (protein)


NP_001229849 NP_001229850 NP_006218 NP_872617


NP_035255

Location (UCSC)

Chr 20: 45.9 – 45.91 Mb

Chr 2: 164.68 – 164.7 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Phospholipid transfer protein is a protein that in humans is encoded by the PLTP gene.

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Transcription

Function

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.^[5]

Interactions

PLTP has been shown to interact with Apolipoprotein A1^[6] and APOA2.^[6]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^[§ 1]

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|alt=Statin Pathway edit]]

Statin Pathway edit

^ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100979 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017754 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PLTP phospholipid transfer protein".
^ ^a ^b Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. 39 (1): 152–61. doi:10.1016/S0022-2275(20)34211-5. PMID 9469594.

Jiang XC (2002). "The effect of phospholipid transfer protein on lipoprotein metabolism and atherosclerosis". Front. Biosci. 7 (1–3): d1634-41. doi:10.2741/jiang1. PMID 12086920.
Albers JJ, Cheung MC (2004). "Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism". Curr. Opin. Lipidol. 15 (3): 255–60. doi:10.1097/00041433-200406000-00004. PMID 15166780. S2CID 34754445.
Dallinga-Thie GM, Dullaart RP, van Tol A (2007). "Concerted actions of cholesteryl ester transfer protein and phospholipid transfer protein in type 2 diabetes: effects of apolipoproteins". Curr. Opin. Lipidol. 18 (3): 251–7. doi:10.1097/MOL.0b013e3280e12685. PMID 17495597. S2CID 20012553.
Whitmore TE, Day JR, Albers JJ (1995). "Localization of the human phospholipid transfer protein gene to chromosome 20q12-q13.1". Genomics. 28 (3): 599–600. doi:10.1006/geno.1995.1198. PMID 7490104.
Albers JJ, Wolfbauer G, Cheung MC, Day JR, Ching AF, Lok S, Tu AY (1995). "Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies". Biochim. Biophys. Acta. 1258 (1): 27–34. doi:10.1016/0005-2760(95)00091-p. PMID 7654777.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Day JR, Albers JJ, Lofton-Day CE, Gilbert TL, Ching AF, Grant FJ, O'Hara PJ, Marcovina SM, Adolphson JL (1994). "Complete cDNA encoding human phospholipid transfer protein from human endothelial cells". J. Biol. Chem. 269 (12): 9388–91. doi:10.1016/S0021-9258(17)37120-X. PMID 8132678.
Tu AY, Wolfbauer G, Albers JJ (1995). "Functional characterization of the promoter region of the human phospholipid transfer protein gene". Biochem. Biophys. Res. Commun. 217 (3): 705–11. doi:10.1006/bbrc.1995.2830. PMID 8554588.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Hailman E, Albers JJ, Wolfbauer G, Tu AY, Wright SD (1996). "Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein". J. Biol. Chem. 271 (21): 12172–8. doi:10.1074/jbc.271.21.12172. PMID 8647810.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (1998). "Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: location of a PLTP binding domain in the amino terminal region of apoA-I". J. Lipid Res. 39 (1): 152–61. doi:10.1016/S0022-2275(20)34211-5. PMID 9469594.
Jiang XC, D'Armiento J, Mallampalli RK, Mar J, Yan SF, Lin M (1998). "Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia". J. Biol. Chem. 273 (25): 15714–8. doi:10.1074/jbc.273.25.15714. PMID 9624168.
Jauhiainen M, Huuskonen J, Baumann M, Metso J, Oka T, Egashira T, Hattori H, Olkkonen VM, Ehnholm C (1999). "Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I". J. Lipid Res. 40 (4): 654–64. doi:10.1016/S0022-2275(20)32144-1. PMID 10191289.
Qu SJ, Fan HZ, Kilinc C, Pownall HJ (1999). "Role of cysteine residues in human plasma phospholipid transfer protein". J. Protein Chem. 18 (2): 193–8. doi:10.1023/A:1020628006453. PMID 10333293. S2CID 1653738.
Lie J, de Crom R, Jauhiainen M, van Gent T, van Haperen R, Scheek L, Jansen H, Ehnholm C, van Tol A (2001). "Evaluation of phospholipid transfer protein and cholesteryl ester transfer protein as contributors to the generation of pre beta-high-density lipoproteins". Biochem. J. 360 (Pt 2): 379–85. doi:10.1042/0264-6021:3600379. PMC 1222238. PMID 11716766.
Kärkkäinen M, Oka T, Olkkonen VM, Metso J, Hattori H, Jauhiainen M, Ehnholm C (2002). "Isolation and partial characterization of the inactive and active forms of human plasma phospholipid transfer protein (PLTP)". J. Biol. Chem. 277 (18): 15413–8. doi:10.1074/jbc.M112247200. PMID 11854286.
Murdoch SJ, Wolfbauer G, Kennedy H, Marcovina SM, Carr MC, Albers JJ (2002). "Differences in reactivity of antibodies to active versus inactive PLTP significantly impacts PLTP measurement". J. Lipid Res. 43 (2): 281–9. doi:10.1016/S0022-2275(20)30170-X. PMID 11861670.

v t e Lipids: lipoprotein particle metabolism
Lipoprotein particle classes and subclasses	delivery of TGs: Chylomicron VLDL delivery of C and CE: IDL LDL lb LDL sd LDL Lp(a) HDL Remnant cholesterol
Apolipoproteins	APOA 1 2 4 5 APOB APOC 1 2 3 4 APOD APOE APOH SAA SAA1
Extracellular enzymes	LCAT LIPC LPL
Lipid transfer proteins	CETP MTTP PLTP
Cell surface receptors	HDL: SCARB1 IDL: LRP LRP1 LRP1B LRP2 LRP3 LRP4 LRP5 LRP5L LRP6 LRP8 LRP10 LRP11 LRP12 LDL: LDLR LRPAP1
ATP-binding cassette transporter	ABCA1 ABCG5 ABCG8

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This page was last edited on 17 November 2023, at 08:09

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