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Xiaodong Wang (U Texas Southwestern/HHMI) Part 2: The Intrinsic Pathway of Apoptosis
#15 Biochemistry Enzyme Regulation II Lecture for Kevin Ahern's BB 450/550
Chapter 5 Part 1 Viral Structure
#19 Biochemistry Signaling II Lecture for Kevin Ahern's BB 450/550
Transcription
Function
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the endoplasmic reticulum (ER) to generate a heterodimer which exits the ER and sorts to the cis/medial-Golgi where a second autocatalytic event takes place and the catalytic activity is acquired. It encodes a type 1 membrane bound protease which is ubiquitously expressed and regulates cholesterol or lipid homeostasis via cleavage of substrates at non-basic residues.[5]
Clinical significance
Mutations in this gene may be associated with lysosomal dysfunction.[5]