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Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.[7]
Yousef GM, Luo LY, Diamandis EP (2000). "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4". Anticancer Res. 19 (4B): 2843–52. PMID10652563.
Yousef GM, Chang A, Scorilas A, Diamandis EP (2000). "Genomic organization of the human kallikrein gene family on chromosome 19q13.3-q13.4". Biochem. Biophys. Res. Commun. 276 (1): 125–33. doi:10.1006/bbrc.2000.3448. PMID11006094.
Gan L, Lee I, Smith R, et al. (2001). "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region". Gene. 257 (1): 119–30. doi:10.1016/S0378-1119(00)00382-6. PMID11054574.
Yousef GM, Magklara A, Diamandis EP (2001). "KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer". Genomics. 69 (3): 331–41. doi:10.1006/geno.2000.6346. PMID11056051.
Shinmura K, Tao H, Yamada H, et al. (2005). "Splice-site genetic polymorphism of the human kallikrein 12 (KLK12) gene correlates with no substantial expression of KLK12 protein having serine protease activity". Hum. Mutat. 24 (3): 273–4. doi:10.1002/humu.9270. PMID15300858. S2CID39475520.
Memari N, Jiang W, Diamandis EP, Luo LY (2007). "Enzymatic properties of human kallikrein-related peptidase 12 (KLK12)". Biol. Chem. 388 (4): 427–35. doi:10.1515/BC.2007.049. PMID17391064. S2CID25034775.
External links
The MEROPS online database for peptidases and their inhibitors: S01.020
This page was last edited on 29 September 2022, at 21:33