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| Clinical data | |
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| Trade names | Dequadin, Fluomizin, Vablys, others |
| Routes of administration | By mouth intravaginal |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.007.575 |
| Chemical and physical data | |
| Formula | C30H40N4 |
| Molar mass | 456.678 g·mol−1 |
| 3D model (JSmol) | |
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Dequalinium is a quaternary ammonium cation and bolaamphiphile commonly available as the dichloride salt. It is useful as an antiseptic and disinfectant. The bromide, iodide, acetate, and undecenoate salts are known as well. Dequalinium chloride is the active ingredient of several medications.
The dequalinium dication is symmetrical, containing two quaternary quinolinium units linked by an N-decylene chain.
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How to Cure a Sore Throat Instantly
Transcription
Hey guys, Dr. Axe here. In this video, I'm going to share with you my top natural strategies to cure a sore throat, and my top home remedies for sore throats. And these are very easy things or simple things that a lot of you guys probably already have stocked in your at-home medicine cabinet. There are really four main things that can help you cure a sore throat very, very fast. The first thing that you can be doing is olive leaf extract. Olive leaf extract, you can find at any health food store out there today. But olive leaf can kill off bad bacteria in your body, fungus, and especially, it's an anti-viral. So doing olive leaf extract is one of the top things you can do to help you cure a sore throat. The second thing you can start doing is colloidal silver. Colloidal silver actually has anti-viral and anti-bacterial activity in it, and so it is very, very powerful as well at things that can typically cause a sore throat. And actually, one of the best things you can do with colloidal silver is you can buy a colloidal silver throat spray, or put colloidal silver in a spray bottle and just spray it right in the back of your throat. Very, very effective natural treatment when it comes to treating sore throat. The third thing you can do is sea salt. Salt water actually has a soothing effect, and that can actually help naturally treat a sore throat as well. So again, if you do have a sore throat, I recommend doing a little bit of sea salt mixed in warm water and gargling that several times a day. That can help you kick a sore throat. And last but not least, using essential oils, specifically lemon oil, oregano oil, and peppermint essential oil. Those are what I believe to be the three most effective essential oils at naturally curing a sore throat. And so one of the other things you might even consider doing is taking a colloidal silver, putting that in a spray bottle along with a mixture of oregano oil, lemon essential oil, and peppermint oil and making a spray and doing that every 30 minutes. That will naturally help your body heal a sore throat. Now, a few other tips that are vitally important when healing a sore throat is getting plenty of rest and sleep. You really want to give your body as much time to recover as you can. So try to sleep 9 to 10 hours a night. Getting to bed early is very, very important. One of the other things you may consider doing as well is really changing your diet, laying off the sugar, grains, and doing mostly bone broth. I recommend making a homemade vegetable soup, basically doing something like chicken broth with vegetables and a little bit of chicken. But again, broth, vegetables and a chicken in crock pot is ideal. So doing that vegetable soup for every meal throughout the day along with those natural treatments of olive leaf extract, sea salt, the essential oils, and again, colloidal silver, and doing that as a throat spray. Those are some of the fastest ways to naturally cure a sore throat. And if you want to learn other natural home remedies to cure a sore throat, you can go and visit my website, draxe.com. That's draxe.com. I actually have some other tips for naturally boosting your immune system this type [sic] of year that can keep your from getting a sore throat or that can help you kick it in 24 hours or less. Check those out at draxe.com. Hey, thanks guys for watching.
Medical uses
Dequalinium chloride 0.25 mg is available as an over-the-counter throat lozenge under brand names such as Dequadin and SP Troche. Mouthwash and buccal sprays at 0.5 % concentration are also available.[3][unreliable medical source?] In this form is it used to treat minor infections of the mouth and throat. It can help with tonsillitis but is not effective in cases of streptococci infections.[4]
The product is also available as a 10 mg prescription vaginal tablet for treating vaginal bacterial conditions (i.e. bacterial Vaginosis and aerobic vaginitis). Brand names include Fluomizin and Vablys.[3]
In Austria, dequalinium chloride is combined with bacitracin and diphenylpyraline in Eucillin "B", an antibiotic cream. This cream is the first dequalinium-containing product to enter Austria in 1967.[3]
Spectrum of activity
Dequalinium salts have broad bactericidal and fungicidal activity.[5] In OTC oral products containing a low concentration, the product is instead described as a bacteriostat.[citation needed]
Dequalinium salts may have antimalarial activities.[6]
Adverse effects
Dequalinium may cause skin necrosis "if administered on intertriginous skin areas under occlusive conditions".[6]
History
Dequalinium was first described by M Babbs and colleagues in 1956, as the first agent of the bisquaternary ammonium chemical class.[7]
References
- ^ "Health product highlights 2021: Annexes of products approved in 2021". Health Canada. 3 August 2022. Retrieved 25 March 2024.
- ^ "Fluomizin Summary of Product Characteristics (SmPC)". (emc). 12 October 2022. Retrieved 14 April 2024.
- ^ a b c "Dequalinium". DrugBank Online.
- ^ Krämer W (April 1977). "[Treatment of tonsillitis with dequalinium chloride]". Fortschritte der Medizin (in German). 95 (16): 1108–1110. PMID 856702.
- ^ Mendling W, Weissenbacher ER, Gerber S, Prasauskas V, Grob P (March 2016). "Use of locally delivered dequalinium chloride in the treatment of vaginal infections: a review". Archives of Gynecology and Obstetrics. 293 (3): 469–484. doi:10.1007/s00404-015-3914-8. PMC 4757629. PMID 26506926.
- ^ a b Tischer M, Pradel G, Ohlsen K, Holzgrabe U (January 2012). "Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions?". ChemMedChem. 7 (1): 22–31. doi:10.1002/cmdc.201100404. PMID 22113995. S2CID 26326417.
- ^ Babbs M, Collier HO, Austin WC, Potter MD, Taylor EP (February 1956). "Salts of decamethylene-bis-4-aminoquinaldinium (dequadin); a new antimicrobial agent". The Journal of Pharmacy and Pharmacology. 8 (2): 110–119. doi:10.1111/j.2042-7158.1956.tb12138.x. PMID 13307403. S2CID 30103639.
Further reading
- Gamboa-Vujicic G, Emma DA, Liao SY, Fuchtner C, Manetta A (March 1993). "Toxicity of the mitochondrial poison dequalinium chloride in a murine model system". Journal of Pharmaceutical Sciences. 82 (3): 231–235. doi:10.1002/jps.2600820302. PMID 8450414.
External links
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This page was last edited on 14 April 2024, at 22:59