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Clobenpropit

From Wikipedia, the free encyclopedia

Clobenpropit
Clinical data
ATC code
  • None
Legal status
Legal status
Identifiers
  • N'-[(4-chlorophenyl)methyl]-1-[3-(3H-imidazol-4-yl)propylsulfanyl]formamidine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H17ClN4S
Molar mass308.83 g·mol−1
3D model (JSmol)
  • C1=CC(=CC=C1CN=C(N)SCCCC2=CN=CN2)Cl

Clobenpropit is a histamine H3 receptor antagonist.[1] It has neuroprotective effects via stimulation of GABA release in brain cells in vitro.[2]

YouTube Encyclopedic

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  • Histamine antagonist

Transcription

References

  1. ^ Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). "The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes". European Journal of Pharmacology. 567 (3): 206–210. doi:10.1016/j.ejphar.2007.04.032. PMID 17537431.
  2. ^ Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z (2007). "The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons". European Journal of Pharmacology. 563 (1–3): 117–123. doi:10.1016/j.ejphar.2007.01.069. PMID 17350613.


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This page was last edited on 13 November 2022, at 01:31
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