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Iodophenpropit

From Wikipedia, the free encyclopedia

Iodophenpropit
Names
IUPAC name
3-(1H-imidazol-5-yl)propyl N'-[2-(4-iodophenyl)ethyl]imidothiocarbamate
Other names
1-[3-(3H-imidazol-4-yl)propylthio]-N'-[2-(4-iodophenyl)ethyl]formamidine
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
MeSH Iodophenpropit
UNII
  • C1=CC(=CC=C1CCN=C(N)SCCCC2=CN=CN2)I
Properties
C15H19IN4S
Molar mass 414.30763 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Iodophenpropit is a histamine antagonist which binds selectively to the H3 subtype. Its 125I radiolabelled form has been used for mapping the distribution of H3 receptors in animal studies.[1][2]

References

  1. ^ Jansen, FP; Wu, TS; Voss, HP; Steinbusch, HW; Vollinga, RC; Rademaker, B; Bast, A; Timmerman, H (1994). "Characterization of the binding of the first selective radiolabelled histamine H3-receptor antagonist, 125I-iodophenpropit, to rat brain". British Journal of Pharmacology. 113 (2): 355–62. doi:10.1111/j.1476-5381.1994.tb16995.x. PMC 1510107. PMID 7834183.
  2. ^ Jansen, FP; Mochizuki, T; Maeyama, K; Leurs, R; Timmerman, H (2000). "Characterization of histamine H3 receptors in mouse brain using the H3 antagonist 125Iiodophenpropit". Naunyn-Schmiedeberg's Archives of Pharmacology. 362 (1): 60–7. doi:10.1007/s002100000227. PMID 10935534. S2CID 21293180.
This page was last edited on 4 February 2024, at 17:46
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