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Triprolidine

From Wikipedia, the free encyclopedia

This article is about the drug. For the Roman province, see Tripolitania. For the city, see Tripoli.
Triprolidine
Clinical data
Trade namesFlonase Nighttime Allergy Relief, Actidil, Myidil, Actifed (in the latter combined with pseudoephedrine and either dextromethorphan or guaifenesin)
AHFS/Drugs.comMonograph
Pregnancy
category
  • C (US)
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability4% oral
Protein binding90%
MetabolismHepatic (CYP2D6)
Elimination half-life4–6 hours
ExcretionRenal
Identifiers
  • 2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-
    prop-1-enyl]pyridine
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.006.934 Edit this at Wikidata
Chemical and physical data
FormulaC19H22N2
Molar mass278.399 g·mol−1
3D model (JSmol)
Melting point60 °C (140 °F)
Solubility in water500 mg/mL (20 °C)
  • n3c(\C(=C\CN1CCCC1)c2ccc(cc2)C)cccc3
  • InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+ checkY
  • Key:CBEQULMOCCWAQT-WOJGMQOQSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Triprolidine is an over-the-counter antihistamine with anticholinergic properties.[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.[2] As with many antihistamines, the most common side effect is drowsiness.[1]

It was patented in 1948 and came into medical use in 1953.[3]

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  • SYNTHESIS OF TRIPROLIDINE | PHARMACEUTICAL CHEMISTRY
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  • Triprolidine Synthesis (Antihistaminics)(Antiallergic)(Alkylamine) - Med Chem Sem 5th
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  • Synthesis of diphenhydramine। L-3। U-1। Triprolidine। Promethazine। H1 antagonist। B Pharm 5th sem।

Transcription

See also

References

  1. ^ a b Goldsmith P, Dowd PM (January 1993). "The new H1 antihistamines. Treatment of urticaria and other clinical problems". Dermatologic Clinics. 11 (1): 87–95. doi:10.1016/S0733-8635(18)30285-7. PMID 8094649.
  2. ^ Williams BO, Liao SH, Lai AA, Arnold JD, Perkins JG, Blum MR, Findlay JW (1984). "Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products". Clinical Pharmacy. 3 (6): 638–43. PMID 6509877.
  3. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 546. ISBN 9783527607495.
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This page was last edited on 6 January 2024, at 06:53
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