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Endosialin is a member of the “Group XIV”, a novel family of C-type lectin transmembrane receptors which play a role not only in cell–cell adhesion processes but also in host defence. This family comprise three other members, CLEC14A, CD93 and Thrombomodulin the latter of which are better characterized. [8]
The function of endosialin remains elusive, but its expression has been associated with angiogenesis in the embryo and uterus and in tumor development and growth.[9]
^Rupp C, Dolznig H, Puri C, Sommergruber W, Kerjaschki D, Rettig WJ, Garin-Chesa P (2006). "Mouse endosialin, a C-type lectin-like cell surface receptor: expression during embryonic development and induction in experimental cancer neoangiogenesis". Cancer Immun. 6: 10. PMID16875435.
Dolznig H, Schweifer N, Puri C, et al. (2006). "Characterization of cancer stroma markers: in silico analysis of an mRNA expression database for fibroblast activation protein and endosialin". Cancer Immun. 5: 10. PMID16076089.
This page was last edited on 4 March 2023, at 00:24