CD24

CD24
Identifiers
Aliases	CD24, CD24A, CD24 molecule
External IDs	OMIM: 600074 GeneCards: CD24
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 106,969,831 bp[1] End 106,975,627 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla bronchial epithelial cell oral cavity parotid gland pancreatic epithelial cell gallbladder pancreatic ductal cell seminal vesicula thyroid gland left lobe of thyroid gland n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein tyrosine kinase activator activity signal transducer activity protein binding protein kinase binding Cellular component membrane plasma membrane cell surface anchored component of external side of plasma membrane membrane raft anchored component of membrane intracellular anatomical structure Biological process response to hypoxia regulation of MAPK cascade positive regulation of MAP kinase activity regulation of cytokine-mediated signaling pathway positive regulation of cytosolic calcium ion concentration chemokine receptor transport out of membrane raft T cell costimulation regulation of phosphorylation Wnt signaling pathway negative regulation of transforming growth factor beta3 production cell activation immune response-regulating cell surface receptor signaling pathway response to estrogen respiratory burst intrinsic apoptotic signaling pathway glomerular parietal epithelial cell differentiation cell adhesion glomerular visceral epithelial cell differentiation cholesterol homeostasis regulation of epithelial cell differentiation response to molecule of bacterial origin cell migration B cell receptor transport into membrane raft positive regulation of nephron tubule epithelial cell differentiation positive regulation of activated T cell proliferation positive regulation of protein tyrosine kinase activity cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 100133941 n/a Ensembl ENSG00000272398 n/a UniProt P25063 n/a RefSeq (mRNA) NM_001291737 NM_001291738 NM_001291739 NM_013230 NM_001359084 n/a RefSeq (protein) NP_001278666 NP_001278667 NP_001278668 NP_037362 NP_001346013 n/a Location (UCSC) Chr 6: 106.97 – 106.98 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24 gene.^[3] CD24 is a cell adhesion molecule.

Function

CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils^[4] and neutrophil precursors from the myelocyte stage onwards. The encoded protein is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. The protein also contributes to a wide range of downstream signaling networks and is crucial for neural development.^[5] Cross-linking of CD24 on the surface of neutrophils induces apoptosis,^[6] and this appears to be defective in sepsis.^[6] CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined.^{[citation needed]}

References

Further reading

External links

• CD24+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Mouse CD Antigen Chart
• Human CD Antigen Chart
• www.copewithcytokines.de: description of CD24 expression
• CD24 human gene location in the UCSC Genome Browser.
• CD24 human gene details in the UCSC Genome Browser.

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This page was last edited on 11 April 2024, at 16:34