Protein-coding gene in the species Homo sapiens
Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene .[5]
The product of this gene belongs to the serine/threonine protein kinase cluster, and to the Ca2+ /calmodulin-dependent protein kinase (CAMK) group. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes , neurons , and male germ cells .[6]
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References Further reading
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Chatila T, Anderson KA, Ho N, Means AR (1996). "A unique phosphorylation-dependent mechanism for the activation of Ca2+ /calmodulin-dependent protein kinase type IV/GR" . J. Biol. Chem . 271 (35): 21542–8. doi :10.1074/jbc.271.35.21542 PMID 8702940 . Melander Gradin H, Marklund U, Larsson N, et al. (1997). "Regulation of microtubule dynamics by Ca2+ /calmodulin-dependent kinase IV/Gr-dependent phosphorylation of oncoprotein 18" . Mol. Cell. Biol . 17 (6): 3459–67. doi :10.1128/mcb.17.6.3459 . PMC 232199 PMID 9154845 . Matsushita M, Nairn AC (1998). "Characterization of the mechanism of regulation of Ca2+ / calmodulin-dependent protein kinase I by calmodulin and by Ca2+ /calmodulin-dependent protein kinase kinase" . J. Biol. Chem . 273 (34): 21473–81. doi :10.1074/jbc.273.34.21473 PMID 9705275 . Anderson KA, Means RL, Huang QH, et al. (1998). "Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+ /calmodulin-dependent protein kinase kinase beta" . J. Biol. Chem . 273 (48): 31880–9. doi :10.1074/jbc.273.48.31880 PMID 9822657 . Hayashi Y, Nishio M, Naito Y, et al. (1999). "Regulation of neuronal nitric-oxide synthase by calmodulin kinases" . J. Biol. Chem . 274 (29): 20597–602. doi :10.1074/jbc.274.29.20597 PMID 10400690 . Blaeser F, Ho N, Prywes R, Chatila TA (2000). "Ca2+ -dependent gene expression mediated by MEF2 transcription factors" . J. Biol. Chem . 275 (1): 197–209. doi :10.1074/jbc.275.1.197 PMID 10617605 . Moreno CS, Park S, Nelson K, et al. (2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A" . J. Biol. Chem . 275 (8): 5257–63. doi :10.1074/jbc.275.8.5257 PMC 3505218 PMID 10681496 . Komeima K, Hayashi Y, Naito Y, Watanabe Y (2000). "Inhibition of neuronal nitric-oxide synthase by calcium/ calmodulin-dependent protein kinase IIalpha through Ser847 phosphorylation in NG108-15 neuronal cells" . J. Biol. Chem . 275 (36): 28139–43. doi :10.1074/jbc.M003198200 PMID 10874031 . Wu JY, Ribar TJ, Cummings DE, et al. (2000). "Spermiogenesis and exchange of basic nuclear proteins are impaired in male germ cells lacking Camk4". Nat. Genet . 25 (4): 448–52. doi :10.1038/78153 . PMID 10932193 . S2CID 10803791 . Jang MK, Goo YH, Sohn YC, et al. (2001). "Ca2+ /calmodulin-dependent protein kinase IV stimulates nuclear factor-kappa B transactivation via phosphorylation of the p65 subunit" . J. Biol. Chem . 276 (23): 20005–10. doi :10.1074/jbc.M010211200 PMID 11274168 . Hsu LS, Chen GD, Lee LS, et al. (2001). "Human Ca2+ /calmodulin-dependent protein kinase kinase beta gene encodes multiple isoforms that display distinct kinase activity" . J. Biol. Chem . 276 (33): 31113–23. doi :10.1074/jbc.M011720200 PMID 11395482 . Zhao X, Ito A, Kane CD, et al. (2001). "The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking" . J. Biol. Chem . 276 (37): 35042–8. doi :10.1074/jbc.M105086200 PMID 11470791 . Ainhoa Bilbaoa; Jan Rodriguez Parkitnab; David Engblomb; Stéphanie Perreau-Lenza; Carles Sanchis-Seguraa; Miriam Schneidera; Witold Konopkab; Magdalena Westphalb; Gerome Breenc; Sylvane Desrivieresc; Matthias Klugmannd; Camila Guindalinie; Homero Valladag; Ronaldo Laranjeirae; Fernando Rodriguez de Fonsecah; Gunter Schumannc; Günther Schützb & Rainer Spanagela (2008). "Loss of the Ca2+ /calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine" . Proceedings of the National Academy of Sciences of the United States of America . PNAS. 105 (45): 17549–54. Bibcode :2008PNAS..10517549B . doi :10.1073/pnas.0803959105 PMC 2582267 PMID 19001277 . Feliciano DM, Edelman AM (2009). "Repression of Ca2+ /calmodulin-dependent protein kinase IV signaling accelerates retinoic acid-induced differentiation of human neuroblastoma cells" . J. Biol. Chem . 284 (39): 26466–81. doi :10.1074/jbc.M109.027680 PMC 2785335 PMID 19633294 .
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Activity Regulation Classification Kinetics Types
This page was last edited on 15 November 2022, at 04:25
This page was last edited on 15 November 2022, at 04:25