Protein-coding gene in the species Homo sapiens
Kinase suppressor of Ras 1 is an enzyme that in humans is encoded by the KSR1 gene .[5] [6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000141068 - Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018334 - Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Therrien M, Chang HC, Solomon NM, Karim FD, Wassarman DA, Rubin GM (Jan 1996). "KSR, a novel protein kinase required for RAS signal transduction" . Cell . 83 (6): 879–88. doi :10.1016/0092-8674(95)90204-X PMID 8521512 . S2CID 16975824 . ^ "Entrez Gene: KSR1 kinase suppressor of ras 1" .
Further reading
Goettel JA, Liang D, Hilliard VC, et al. (2011). "KSR1 is a functional protein kinase capable of serine autophosphorylation and direct phosphorylation of MEK1" . Exp. Cell Res . 317 (4): 452–63. doi :10.1016/j.yexcr.2010.11.018 . PMC 3038243 PMID 21144847 . Kolesnick R, Xing HR (2004). "Inflammatory bowel disease reveals the kinase activity of KSR1" . J. Clin. Invest . 114 (9): 1233–7. doi :10.1172/JCI23441 . PMC 524240 PMID 15520853 . Xing HR, Lozano J, Kolesnick R (2000). "Epidermal growth factor treatment enhances the kinase activity of kinase suppressor of Ras" . J. Biol. Chem . 275 (23): 17276–80. doi :10.1074/jbc.C900989199 PMID 10764733 . Roy F, Therrien M (2002). "MAP kinase module: the Ksr connection" . Curr. Biol . 12 (9): R325–7. Bibcode :2002CBio...12.R325R . doi :10.1016/S0960-9822(02)00831-X PMID 12007434 . S2CID 17763459 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Matheny SA, Chen C, Kortum RL, et al. (2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature . 427 (6971): 256–60. Bibcode :2004Natur.427..256M . doi :10.1038/nature02237 . PMID 14724641 . S2CID 4416552 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Kim M, Yan Y, Kortum RL, et al. (2005). "Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity" . Cancer Res . 65 (10): 3986–92. doi :10.1158/0008-5472.CAN-03-2334 PMID 15899786 . Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage" . Nature . 440 (7087): 1045–9. Bibcode :2006Natur.440.1045Z . doi :10.1038/nature04689 . PMC 2610434 PMID 16625196 . Wang X, Wang TT, White JH, Studzinski GP (2006). "Induction of kinase suppressor of RAS-1(KSR-1) gene by1, α25-dihydroxyvitamin D3 in human leukemia HL60 cells through a vitamin D response element in the 5′-flanking region" . Oncogene . 25 (53): 7078–85. doi :10.1038/sj.onc.1209697 . PMC 2843694 PMID 16732322 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 .
Activity Regulation Classification Kinetics Types
This page was last edited on 3 April 2024, at 16:09
This page was last edited on 3 April 2024, at 16:09