Lithium aspartate

Lithium aspartate
Clinical data

AHFS/Drugs.com	Monograph
Routes of administration	Oral
Legal status
Legal status	In general: Over-the-counter (OTC)
Identifiers
CAS Number	70962-88-8^Y
PubChem CID	71587253
ChemSpider	34994320^N
UNII	L2N7Z24B30
Chemical and physical data
Formula	C₄H₆LiNO₄
Molar mass	139.04 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES [Li+].N[C@@H](CC(O)=O)C([O-])=O
InChI InChI=InChI=1S/C4H7NO4.Li/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H,6,7)(H,8,9);/q;+1/p-1/t2-;/m0./s1^N Key:NFNOWBZQMRFQDG-DKWTVANSSA-M^N

Lithium aspartate (C₄H₆LiNO₄) is a salt of aspartic acid and lithium. It is sometimes marketed as a dietary supplement used in small doses to treat certain medical conditions; however, there are no systematic reviews supporting the efficacy, or safety, of lithium aspartate and it is not approved by the U.S. Food and Drug Administration (FDA) for the treatment of any medical condition. Published research on lithium aspartate is sparse.^[1]^[2]^[3]

Aspartic acid stimulates the NMDA receptor.^[4]

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References

^ Müller-Oerlinghausen B, Imiela M (June 1986). "Is lithium aspartate at low serum levels more effective than the usual lithium salts?". Nervenarzt. 57 (6): 370–3. PMID 3736729.
^ Olbrich R, Watzl H, Völter M, Siedow H (March 1991). "Lithium in the treatment of chronic alcoholic patients with brain damage--a controlled study". Nervenarzt. 62 (3): 182–6. PMID 2052117.
^ Daunderer M (September 1982). "Lithium aspartate in drug dependence". Fortschr. Med. 100 (33): 1500–2. PMID 7129311.
^ Chen PE, Geballe MT, Stansfeld PJ, Johnston AR, Yuan H, Jacob AL, Snyder JP, Traynelis SF, Wyllie DJ (May 2005). "Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling". Molecular Pharmacology. 67 (5): 1470–84. doi:10.1124/mol.104.008185. PMID 15703381. S2CID 13505187.

External links

Lithium – The Misunderstood Mineral Part 1 article on lithium compounds by Jonathan Wright, M.D.

v t e Mood stabilizers
Anticonvulsants	Carbamazepine Lamotrigine Oxcarbazepine Valproate Valnoctamide Valproate pivoxil Valpromide
Atypical antipsychotics	Aripiprazole Asenapine Cariprazine Clozapine Lurasidone Olanzapine (+fluoxetine) Paliperidone Quetiapine Risperidone Ziprasidone
Others	Ketamine Lithium (lithium acetate, lithium carbonate, lithium chloride, lithium citrate, lithium hydroxide, lithium orotate) Omega-3 fatty acids (docosahexaenoic acid, eicosapentaenoic acid)

Mood disorder

Spectrum

Bipolar disorder	Bipolar I Bipolar II Cyclothymia Bipolar NOS Childhood Hypomania Mania Mixed affective state Rapid cycling
Depression	Major depressive disorder Dysthymia Seasonal affective disorder Atypical depression Melancholic depression Major depressive episode Depression in childhood and adolescence
Comorbidities	Schizoaffective disorder

Symptoms

Diagnosis

Treatment

Anticonvulsants	Carbamazepine Lamotrigine Oxcarbazepine Valproate Sodium valproate Valproate semisodium
Sympathomimetics, SSRIs and similar	Bupropion Dextroamphetamine Escitalopram Fluoxetine Methylphenidate Sertraline
Other mood stabilizers	Antipsychotics Atypical antipsychotics Lithium Lithium carbonate Lithium citrate Lithium sulfate Lithium toxicity
Non-pharmaceutical	Clinical psychology Cognitive behavioral therapy Dialectical behavior therapy Electroconvulsive therapy Involuntary commitment Light therapy Psychotherapy Transcranial magnetic stimulation

History

v t e Lithium compounds
Inorganic (list)	Li₂ LiAlCl₄ Li_1+xAl_xGe_2−x(PO₄)₃ LiAlH₄ LiAlO₂ <span class="nowrap">LiAl<sub>1+x</sub>Ti<sub>2−x</sub>(PO<sub>4</sub>)<sub>3</sub></span> LiAs LiAsF<sub>6</sub> Li<sub>3</sub>AsO<sub>4</sub> LiAt <span class="nowrap">Li[AuCl<sub>4</sub></span>] LiB(C<sub>2</sub>O<sub>4</sub>)<sub>2</sub> LiB(C₆F₅)₄ LiBF₄ LiBH₄ LiBO₂ LiB₃O₅ Li₂B₄O₇ Li₂TiF₆ Li₂ZrF₆ <span class="nowrap">Li<sub>2</sub>B<sub>4</sub>O<sub>7</sub>·5H<sub>2</sub>O</span> LiBSi<sub>2</sub> LiBr <span class="nowrap">LiBr·2H<sub>2</sub>O</span> LiBrO LiBrO<sub>2</sub> LiBrO<sub>3</sub> LiBrO<sub>4</sub> Li₂C₂ LiCF₃SO₃ CH₃CH(OH)COOLi LiC<sub>2</sub>H<sub>2</sub>ClO<sub>2</sub> LiC<sub>2</sub>H<sub>3</sub>IO<sub>2</sub> Li(CH<sub>3</sub>)<sub>2</sub>N LiCHO<sub>2</sub> LiCH₃O LiC<sub>2</sub>H<sub>5</sub>O LiCN Li<sub>2</sub>CN<sub>2</sub> LiCNO Li₂CO₃ Li₂C₂O₄ LiCl LiCl·H₂O LiClO LiFO LiClO<sub>2</sub> LiClO₃ LiClO₄ LiCoO₂ Li<sub>2</sub>CrO<sub>4</sub> <span class="nowrap">Li<sub>2</sub>CrO<sub>4</sub>·2H<sub>2</sub>O</span> Li<sub>2</sub>Cr<sub>2</sub>O<sub>7</sub> CsLiB₆O₁₀ LiD LiF Li<sub>2</sub>F LiF<sub>4</sub>Al Li<sub>3</sub>F<sub>6</sub>Al FLiBe LiFePO₄ FLiNaK LiGaH₄ Li₂GeF₆ Li<sub>2</sub>GeO<sub>3</sub> LiGe<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub> LiH LiH<sub>2</sub>AsO<sub>4</sub> Li<sub>2</sub>HAsO<sub>4</sub> LiHCO₃ Li<sub>3</sub>H(CO<sub>3</sub>)<sub>2</sub> LiH<sub>2</sub>PO<sub>3</sub> LiH<sub>2</sub>PO<sub>4</sub> LiHSO<sub>3</sub> LiHSO<sub>4</sub> LiHe LiI LiIO LiIO<sub>2</sub> LiIO₃ LiIO₄ Li₂IrO₃ Li₇La₃Zr₂O₁₂ <span class="nowrap">LiMn<sub>2</sub>O<sub>4</sub></span> Li₂MoO₄ Li_0.9Mo₆O₁₇ LiN₃ Li₃N LiNH₂ Li₂NH LiNO₂ LiNO₃ <span class="nowrap">LiNO<sub>3</sub>·H<sub>2</sub>O</span> Li<sub>2</sub>N<sub>2</sub>O<sub>2</sub> LiNa Li<sub>2</sub>NaPO<sub>3</sub> LiNaNO₂ LiNbO₃ Li<sub>2</sub>NbO<sub>3</sub> LiO⁻ LiO₂ LiO<sub>3</sub> Li₂O Li₂O₂ LiOH Li₃P LiPF₆ Li<sub>3</sub>PO<sub>4</sub> Li<sub>2</sub>HPO<sub>3</sub> Li<sub>2</sub>HPO<sub>4</sub> Li<sub>3</sub>PO<sub>3</sub> Li<sub>3</sub>PO<sub>4</sub> Li₂Po Li₂PtO₃ Li₂RuO₃ Li₂S LiSCN LiSH LiSO<sub>3</sub>F Li₂SO₃ Li₂SO₄ Li[SbF<sub>6</sub>] Li₂Se Li<sub>2</sub>SeO<sub>3</sub> Li<sub>2</sub>SeO<sub>4</sub> LiSi Li<sub>2</sub>SiF<sub>6</sub> Li₄SiO₄ Li₂SiO₃ Li₂Si₂O₅ LiTaO₃ Li₂Te LiTe₃ Li₂TeO₃ Li<sub>2</sub>TeO<sub>4</sub> Li₂TiO₃ <span class="nowrap">Li<sub>4</sub>Ti<sub>5</sub>O<sub>12</sub></span> <span class="nowrap">LiTi<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub></span> <span class="nowrap">LiVO<sub>3</sub>·2H<sub>2</sub>O</span> Li<sub>3</sub>V<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub> Li₂WO₄ LiYF₄ Neodymium-doped <span class="nowrap">LiZr<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub></span> Li<sub>2</sub>ZrO<sub>3</sub>
Organic (soaps)	Hemolithin (extraterrestrial protein) Organolithium reagents Gilman reagent CH₃COOLi C₄H₆LiNO₄ LiC₂F₆NO₄S₂ LiN(SiMe₃)₂ Li₃C₆H₅O₇ C₅H₅Li LiN(C₃H₇)₂ (C₆H₅)₂PLi C₁₈H₃₅LiO₃ C₆H₁₃Li C₄H₉Li CH₃CHLiCH₂CH₃ (CH₃)₃CLi C₁₂H₂₈BLi CH₃Li Li⁺C₁₀H₈⁻ C₅H₁₁Li C₅H₃LiN₂O₄ C₆H₅Li LiC₂CH₃ LiO₂C(CH₂)₁₆CH₃ C₄H₅LiO₄ LiEt₃BH LiOC(CH₃)₃ C₉H₁₈LiN LiC₂H₃ Vinyllithium LiC ₁₁H ₂₃COO
Minerals	Amblygonite Berezanskite Brannockite Cryolithionite Darapiosite Darrellhenryite Elbaite Fluorine Elbaite Fluor-liddicoatite Emeleusite Eucryptite LiAlSiO₄ Faizievite Hectorite Hsianghualite Jadarite LiNaSiB₃O₇OH Keatite Li(AlSi₂O₆) Kunzite Lavinskyite Lepidolite Lithiophilite LiMnPO₄ Lithiophosphate Li₃PO₄ Manandonite Manganoneptunite Nambulite Neptunite Olympite Petalite LiAlSi₄0₁₀ Pezzottaite Cs(Be₂Li)Al₂Si₆O₁₈ Rossmanite Saliotite Sogdianite Spodumene LiAl(SiO₃)₂ Sugilite Tiptopite Tourmaline Triphylite LiFePO₄ Zabuyelite Li₂CO₃ Zektzerite Zinnwaldite
Hypothetical	Li_xBe_y HLiHe<sup>+</sup> LiFHeO LiHe<sub>2</sub> (HeO)(LiF)<sub>2</sub> La_2/3-xLi_3xTiO₃He
Other Li-related	Aluminium–lithium alloys Heteroatom-promoted lateral lithiation LB buffer Lithium atom Lithium medication LiNi_xCo_yAl_zO₂ LiNi_xMn_yCo_zO₂ Lithium soap Lithium Triangle Lucifer yellow Magnesium–lithium alloys NASICON Environmentally friendly red light flare

This page was last edited on 29 February 2024, at 12:41

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See also

References

External links