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Famprofazone

From Wikipedia, the free encyclopedia

Famprofazone
Clinical data
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 1-methyl-5-{[methyl(1-phenylpropan-2-yl)amino]methyl}-2-phenyl-4-(propan-2-yl)-1,2-dihydro-3H-pyrazol-3-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.041.153 Edit this at Wikidata
Chemical and physical data
FormulaC24H31N3O
Molar mass377.532 g·mol−1
3D model (JSmol)
  • O=C2\C(=C(/N(N2c1ccccc1)C)CN(C(C)Cc3ccccc3)C)C(C)C

Famprofazone (Gewodin, Gewolen) is a nonsteroidal anti-inflammatory agent (NSAID) of the pyrazolone series which is available over-the-counter in some countries such as Taiwan.[1][2][3] It has analgesic, anti-inflammatory, and antipyretic effects.[1][2] Famprofazone has been known to produce methamphetamine as an active metabolite, with 15–20% of an oral dose being converted to it.[4][5] As a result, famprofazone has occasionally been implicated in causing positives on drug tests for amphetamines.[3]

See also

References

  1. ^ a b Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 1932. ISBN 3-88763-075-0.
  2. ^ a b Hall JA, Morton I (1999). Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. p. 342. ISBN 0-7514-0499-3.
  3. ^ a b Chan KH, Hsu MC, Tseng CY, Chu WL (2010). "Famprofazone use can be misinterpreted as methamphetamine abuse". Journal of Analytical Toxicology. 34 (6): 347–353. doi:10.1093/jat/34.6.347. PMID 20663288.
  4. ^ Oh ES, Hong SK, Kang GI (March 1992). "Plasma and urinary concentrations of methamphetamine after oral administration of famprofazone to man". Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 22 (3): 377–384. doi:10.3109/00498259209046649. PMID 1496827.
  5. ^ Shin HS, Park BB, Choi SN, Oh JJ, Hong CP, Ryu H (1998). "Identification of new urinary metabolites of famprofazone in humans". Journal of Analytical Toxicology. 22 (1): 55–60. doi:10.1093/jat/22.1.55. PMID 9491970.
This page was last edited on 23 December 2023, at 08:34
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