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Phenazolam

From Wikipedia, the free encyclopedia

Phenazolam
Clinical data
Trade names(none, designer drug)
Legal status
Legal status
Identifiers
  • 8-bromo-6-(2-chlorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H12BrClN4
Molar mass387.67 g·mol−1
3D model (JSmol)
  • CC1=NN=C2N1C3=C(C=C(C=C3)Br)C(=NC2)C4=CC=CC=C4Cl
  • InChI=1S/C17H12BrClN4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3
  • Key:BUTCFAZTKZDYCN-UHFFFAOYSA-N

Phenazolam, (Clobromazolam, DM-II-90, BRN 4550445) is a benzodiazepine derivative which acts as a potent sedative and hypnotic drug. It was first invented in the early 1980s,[1] but was never developed for medical use. It has been sold over the internet as a designer drug, first being identified in seized samples by a laboratory in Sweden in March 2016.[2][3]

Legality

Clobromazolam was made illegal in Serbia in May 2019,[4] and in Italy in March 2020.[5]

See also

References

  1. ^ Polívka Z, Holubek J, Metyš J, Šedivŷ Z, Protiva M (1983). "Potential hypnotics and anxiolytics: 8-Chloro-6-(2-chlorophenyl)-1-[4-(2-methoxyethyl) piperazino]-methyl-4H-s-triazolo[4,3-a]-1,4-benzodiazepine and related compounds". Collection of Czechoslovak Chemical Communications. 48 (12): 3433–43. doi:10.1135/cccc19833433.
  2. ^ "Novel Benzodiazepines. A review of the evidence of use and harms of Novel Benzodiazepines" (PDF). Advisory Council on the Misuse of Drugs. April 2020.
  3. ^ Wagmann L, Manier SK, Felske C, Gampfer TM, Richter MJ, Eckstein N, Meyer MR (October 2020). "Flubromazolam-Derived Designer Benzodiazepines: Toxicokinetics and Analytical Toxicology of Clobromazolam and Bromazolam". Journal of Analytical Toxicology. 45 (9): 1014–1027. doi:10.1093/jat/bkaa161. PMID 33048135.
  4. ^ ""Службени гласник РС", број 38 од 31. маја 2019" [Rulebook on determining the List of psychoactive controlled substances: 38 / 2019-121] (in Serbian). Serbian Ministry of Health.
  5. ^ "Legislazione - MINISTERO SALUTE - Decreto ministeriale" [Legislation - MINISTRY HEALTH - Ministerial decree] (in Italian). 13 March 2020.
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This page was last edited on 23 March 2024, at 09:30
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