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AM-855 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoidagonist. It is a derivative of Δ8Tetrahydrocannabinol with a conformationally restricted side chain which has been bound into a fourth ring fused to the aromatic A-ring of the cannabinoid skeleton. AM-855 is an agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 22.3 nM at CB1 and 58.6 nM at CB2.[1]
References
^Khanolkar AD, Lu D, Fan P, Tian X, Makriyannis A (August 1999). "Novel conformationally restricted tetracyclic analogs of Δ8-tetrahydrocannabinol". Bioorganic & Medicinal Chemistry Letters. 9 (15): 2119–24. doi:10.1016/S0960-894X(99)00355-8. PMID10465529.
This page was last edited on 12 May 2022, at 19:52