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2-Hydroxysaclofen

From Wikipedia, the free encyclopedia

2-Hydroxysaclofen
Names
IUPAC name
3-amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
EC Number
  • 634-206-2
UNII
  • Key: WBSMZVIMANOCNX-UHFFFAOYSA-N
  • InChI=1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)
  • C1=CC(=CC=C1C(CN)(CS(=O)(=O)O)O)Cl
Properties
C9H12ClNO4S
Molar mass 265.71 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

2-Hydroxysaclofen is a GABAB receptor antagonist and an analogue of saclofen.

Pharmacodynamics

2-Hydroxysaclofen binds to the GABAB receptor, but this is selective for the (S)-enantiomer, while the (R)-enantiomer does not bind to the GABAB protein.[1]

2-Hydroxysaclofen has been reported to be more potent than saclofen.[2]

See also

References

  1. ^ "2 Hydroxysaclofen - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2024-02-03.
  2. ^ "2-Hydroxysaclofen".
This page was last edited on 1 March 2024, at 18:56
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