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BSPP (drug)

From Wikipedia, the free encyclopedia

BSPP
Clinical data
ATC code
  • none
Identifiers
  • 2,6-di-tert-butyl-4-{[1-(hydroxymethyl)cyclopentyl]methyl}phenol
PubChem CID
ChemSpider
Chemical and physical data
FormulaC21H34O2
Molar mass318.501 g·mol−1
3D model (JSmol)
  • C(C)(C)(C)C1=C(C(=CC(=C1)CC1(CCCC1)CO)C(C)(C)C)O
  • InChI=1S/C21H34O2/c1-19(2,3)16-11-15(12-17(18(16)23)20(4,5)6)13-21(14-22)9-7-8-10-21/h11-12,22-23H,7-10,13-14H2,1-6H3 checkY
  • Key:CTFKOMUXSHQLLL-UHFFFAOYSA-N checkY
  (verify)

BSPP is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.[1] It has a synergistic effect with GABAB agonists such as baclofen at GABAB autoreceptors but not heteroreceptors, suggesting it may be useful for distinguishing between these GABAB receptor subtypes.[2]

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Transcription

References

  1. ^ Kerr DI, Khalafy J, Ong J, Perkins MV, Prager RH, Puspawati NM, Rimaz M (September 2006). "Synthesis and biological activity of allosteric modulators of GABAB receptors, part 2. 3-(2, 6-bis-tert-butyl-4-hydroxyphenyl) propanols". Australian Journal of Chemistry. 59 (7): 457–62. doi:10.1071/CH06164.
  2. ^ Parker DA, Marino V, Ong J, Puspawati NM, Prager RH (September 2008). "The CGP7930 analogue 2,6-di-tert-butyl-4-(3-hydroxy-2-spiropentylpropyl)-phenol (BSPP) potentiates baclofen action at GABA(B) autoreceptors". Clinical and Experimental Pharmacology & Physiology. 35 (9): 1113–5. doi:10.1111/j.1440-1681.2008.04948.x. PMID 18430050. S2CID 25608408.



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This page was last edited on 10 March 2021, at 16:51
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