GNB2L1

Нуклеотидо-связывающий белок гуанина(G-белок), подобный бета полипептиду 2, 1

Доступные структуры

PDB

Поиск ортологов: PDBe, RCSB

Список идентификаторов PDB

3J3A, 4AOW

Идентификаторы

Символ

GNB2L1 ; Gnb2-rs1; H12.3; HLC-7; PIG21; RACK1

Внешние ID

OMIM: 176981 MGI: 101849 HomoloGene: 4446 GeneCards: Ген GNB2L1

Генная онтология

Функция	• protein kinase C binding • receptor binding • protein binding • ion channel inhibitor activity • cysteine-type endopeptidase activator activity involved in apoptotic process • enzyme binding • protein phosphatase binding • protein tyrosine kinase inhibitor activity • receptor tyrosine kinase binding • protein complex scaffold • SH2 domain binding • protein homodimerization activity • poly(A) RNA binding
Компонент клетки	• phagocytic cup • nucleus • cytoplasm • mitochondrion • cytosol • cytoskeleton • small ribosomal subunit • dendrite • midbody • neuronal cell body • perikaryon • perinuclear region of cytoplasm • extracellular vesicular exosome
Биологический процесс	• positive regulation of protein phosphorylation • activation of cysteine-type endopeptidase activity involved in apoptotic process • cell cycle • gastrulation • negative regulation of gene expression • viral process • negative regulation of translation • negative regulation of Wnt signaling pathway • negative regulation of cell growth • positive regulation of cell migration • positive regulation of cAMP catabolic process • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • positive regulation of protein homooligomerization • regulation of protein localization • positive regulation of apoptotic process • negative regulation of neuron apoptotic process • positive regulation of GTPase activity • rhythmic process • negative regulation of phagocytosis • regulation of cell division • positive regulation of cyclic-nucleotide phosphodiesterase activity • regulation of cell cycle • negative regulation of protein kinase B signaling • positive regulation of mitochondrial depolarization • negative regulation of protein tyrosine kinase activity • regulation of establishment of protein localization to plasma membrane • negative regulation of hydrogen peroxide-mediated programmed cell death • regulation of establishment of cell polarity • positive regulation of gastrulation • positive regulation of intrinsic apoptotic signaling pathway
Источники: Amigo / QuickGO

Ортологи

Вид

Человек

Мышь

Entrez

RefSeq (мРНК)

RefSeq (белок)

Локус (UCSC)

Chr 5:
180.66 – 180.68 Mb

Chr 11:
48.8 – 48.81 Mb

Поиск в PubMed

Искать

Гуанидин нуклеотид связывающая субъединица бета-2 (англ. Guanine nucleotide-binding protein subunit beta-2-like 1) также известная как Рецептор для активаци C 1 или RACK1 (англ. Receptor for activated C kinase) — белок массой 32 кДа, кодируемый у человека геном GNB2L1 ^[1]^[2].

Взаимодействия

GNB2L1, как было выявлено, взаимодействует с:

Примечания

↑ Ron D., Chen C.H., Caldwell J., Jamieson L., Orr E., Mochly-Rosen D. Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1994. — March (vol. 91, no. 3). — P. 839—843. — doi:10.1073/pnas.91.3.839. — PMID 8302854. — PMC 521407.
↑ Guillemot F., Billault A., Auffray C. Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1989. — July (vol. 86, no. 12). — P. 4594—4598. — doi:10.1073/pnas.86.12.4594. — PMID 2499885. — PMC 287317.
↑ Yarwood, S J; Steele M R; Scotland G; Houslay M D; Bolger G B. The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform (англ.) // J. Biol. Chem. : journal. — UNITED STATES, 1999. — May (vol. 274, no. 21). — P. 14909—14917. — ISSN 0021-9258. — doi:10.1074/jbc.274.21.14909. — PMID 10329691.
↑ Steele, M R; McCahill A; Thompson D S; MacKenzie C; Isaacs N W; Houslay M D; Bolger G B. Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5 (англ.) // Cell. Signal. (англ.) (рус. : journal. — England, 2001. — July (vol. 13, no. 7). — P. 507—513. — ISSN 0898-6568. — doi:10.1016/S0898-6568(01)00167-X. — PMID 11516626.
↑ ¹ ² ³ Usacheva, Anna; Tian Xinyong; Sandoval Raudel; Salvi Debra; Levy David; Colamonici Oscar R. The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex (англ.) // J. Immunol. (англ.) (рус. : journal. — United States, 2003. — September (vol. 171, no. 6). — P. 2989—2994. — ISSN 0022-1767. — doi:10.4049/jimmunol.171.6.2989. — PMID 12960323.
↑ ¹ ² Usacheva, A; Smith R; Minshall R; Baida G; Seng S; Croze E; Colamonici O. The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor (англ.) // J. Biol. Chem. : journal. — United States, 2001. — June (vol. 276, no. 25). — P. 22948—22953. — ISSN 0021-9258. — doi:10.1074/jbc.M100087200. — PMID 11301323.
↑ Chang, B Y; Conroy K B; Machleder E M; Cartwright C A. RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells (англ.) // Mol. Cell. Biol. (англ.) (рус. : journal. — UNITED STATES, 1998. — June (vol. 18, no. 6). — P. 3245—3256. — ISSN 0270-7306. — PMID 9584165. — PMC 108906.
↑ Rigas, Anastasia C; Ozanne Daniel M; Neal David E; Robson Craig N. The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway (англ.) // J. Biol. Chem. : journal. — United States, 2003. — November (vol. 278, no. 46). — P. 46087—46093. — ISSN 0021-9258. — doi:10.1074/jbc.M306219200. — PMID 12958311.
↑ Wang, Wei; Huang Yan, Zhou Zongxiang, Tang Rong, Zhao Wei, Zeng Li, Xu Ming, Cheng Chao, Gu Shaohua, Ying Kang, Xie Yi, Mao Yumin. Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap) (англ.) // Int. J. Biochem. Cell Biol. (англ.) (рус. : journal. — England, 2002. — January (vol. 34, no. 1). — P. 93—102. — ISSN 1357-2725. — doi:10.1016/S1357-2725(01)00094-2. — PMID 11733189.
↑ Yaka, Rami; He Dao-Yao; Phamluong Khanhky; Ron Dorit. Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1 (англ.) // J. Biol. Chem. : journal. — United States, 2003. — March (vol. 278, no. 11). — P. 9630—9638. — ISSN 0021-9258. — doi:10.1074/jbc.M209141200. — PMID 12524444.
↑ Yaka, Rami; Thornton Claire; Vagts Alicia J; Phamluong Khanhky; Bonci Antonello; Ron Dorit. NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1 (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — United States, 2002. — April (vol. 99, no. 8). — P. 5710—5715. — ISSN 0027-8424. — doi:10.1073/pnas.062046299. — PMID 11943848. — PMC 122836.
↑ Diederichs, Sven; Bäumer Nicole, Ji Ping, Metzelder Stephan K., Idos Gregory E., Cauvet Thomas, Wang Wenbing, Möller Maria, Pierschalski Sarah, Gromoll Jörg, Schrader Mark G., Koeffler H Phillip, Berdel Wolfgang E., Serve Hubert, Müller-Tidow Carsten. Identification of interaction partners and substrates of the cyclin A1-CDK2 complex (англ.) // J. Biol. Chem. : journal. — United States, 2004. — August (vol. 279, no. 32). — P. 33727—33741. — ISSN 0021-9258. — doi:10.1074/jbc.M401708200. — PMID 15159402.
↑ Croze, E; Usacheva A; Asarnow D; Minshall R D; Perez H D; Colamonici O. Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor (англ.) // J. Immunol. (англ.) (рус. : journal. — UNITED STATES, 2000. — November (vol. 165, no. 9). — P. 5127—5132. — ISSN 0022-1767. — doi:10.4049/jimmunol.165.9.5127. — PMID 11046044.
↑ Liedtke, Carole M; Yun C H Chris; Kyle Nicole; Wang Dandan. Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor (англ.) // J. Biol. Chem. : journal. — United States, 2002. — June (vol. 277, no. 25). — P. 22925—22933. — ISSN 0021-9258. — doi:10.1074/jbc.M201917200. — PMID 11956211.
↑ Ozaki, Toshinori; Watanabe Ken-ichi; Nakagawa Takahito; Miyazaki Kou; Takahashi Masato; Nakagawara Akira. Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB (англ.) // Oncogene (англ.) (рус. : journal. — England, 2003. — May (vol. 22, no. 21). — P. 3231—3242. — ISSN 0950-9232. — doi:10.1038/sj.onc.1206382. — PMID 12761493.
↑ Koehler, J A; Moran M F. RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP (англ.) // Biochem. Biophys. Res. Commun. (англ.) (рус. : journal. — United States, 2001. — May (vol. 283, no. 4). — P. 888—895. — ISSN 0006-291X. — doi:10.1006/bbrc.2001.4889. — PMID 11350068.
↑ Ron, D; Jiang Z; Yao L; Vagts A; Diamond I; Gordon A. Coordinated movement of RACK1 with activated betaIIPKC (англ.) // J. Biol. Chem. : journal. — UNITED STATES, 1999. — September (vol. 274, no. 38). — P. 27039—27046. — ISSN 0021-9258. — doi:10.1074/jbc.274.38.27039. — PMID 10480917.
↑ Battle, Michele A; Maher Veronica M; McCormick J Justin. ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways (англ.) // Biochemistry : journal. — United States, 2003. — June (vol. 42, no. 24). — P. 7270—7282. — ISSN 0006-2960. — doi:10.1021/bi034081y. — PMID 12809483.
↑ Hellberg, Carina B; Burden-Gulley Susan M., Pietz Gregory E., Brady-Kalnay Susann M. Expression of the receptor protein-tyrosine phosphatase, PTPmu, restores E-cadherin-dependent adhesion in human prostate carcinoma cells (англ.) // J. Biol. Chem. : journal. — United States, 2002. — March (vol. 277, no. 13). — P. 11165—11173. — ISSN 0021-9258. — doi:10.1074/jbc.M112157200. — PMID 11801604.
↑ Mourton, T; Hellberg C B; Burden-Gulley S M; Hinman J; Rhee A; Brady-Kalnay S M. The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts (англ.) // J. Biol. Chem. : journal. — United States, 2001. — May (vol. 276, no. 18). — P. 14896—14901. — ISSN 0021-9258. — doi:10.1074/jbc.M010823200. — PMID 11278757.
↑ Ceci, Marcello; Gaviraghi Cristina; Gorrini Chiara; Sala Leonardo A; Offenhäuser Nina; Marchisio Pier Carlo; Biffo Stefano. Release of eIF6 (p27BBP) from the 1960s subunit allows 1980s ribosome assembly (англ.) // Nature : journal. — England, 2003. — December (vol. 426, no. 6966). — P. 579—584. — doi:10.1038/nature02160. — PMID 14654845.
↑ Edelmann, Mariola J; Iphöfer Alexander, Akutsu Masato, Altun Mikael, di Gleria Katalin, Kramer Holger B., Fiebiger Edda, Dhe-Paganon Sirano, Kessler Benedikt M. Structural basis and specificity of human otubain 1-mediated deubiquitination (англ.) // Biochem. J. (англ.) (рус. : journal. — England, 2009. — March (vol. 418, no. 2). — P. 379—390. — doi:10.1042/BJ20081318. — PMID 18954305.
↑ ¹ ² Liliental, J; Chang D D. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit (англ.) // J. Biol. Chem. : journal. — UNITED STATES, 1998. — January (vol. 273, no. 4). — P. 2379—2383. — ISSN 0021-9258. — doi:10.1074/jbc.273.4.2379. — PMID 9442085.
↑ Lee, H-S; Millward-Sadler S J; Wright M O; Nuki G; Al-Jamal R; Salter D M. Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction (англ.) // Osteoarthr. Cartil. (англ.) (рус. : journal. — England, 2002. — November (vol. 10, no. 11). — P. 890—897. — ISSN 1063-4584. — doi:10.1053/joca.2002.0842. — PMID 12435334.

Литература

Liu Y.V., Semenza G.L. RACK1 vs. HSP90: competition for HIF-1 alpha degradation vs. stabilization. (англ.) // Cell Cycle (англ.) (рус. : journal. — 2007. — Vol. 6, no. 6. — P. 656—659. — doi:10.4161/cc.6.6.3981. — PMID 17361105.
Mochly-Rosen D., Miller K.G., Scheller R.H. et al. p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C. (англ.) // Biochemistry : journal. — 1992. — Vol. 31, no. 35. — P. 8120—8124. — doi:10.1021/bi00150a003. — PMID 1326322.
Dawson S.J., White L.A. Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. (англ.) // J. Infect. (англ.) (рус. : journal. — 1992. — Vol. 24, no. 3. — P. 317—320. — doi:10.1016/S0163-4453(05)80037-4. — PMID 1602151.
Pumiglia K.M., LeVine H., Haske T. et al. A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase. (англ.) // J. Biol. Chem. : journal. — 1995. — Vol. 270, no. 24. — P. 14251—14254. — doi:10.1074/jbc.270.24.14251. — PMID 7782277.
Maruyama K., Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (англ.) // Gene (англ.) (рус. : journal. — Elsevier, 1994. — Vol. 138, no. 1—2. — P. 171—174. — doi:10.1016/0378-1119(94)90802-8. — PMID 8125298.
Disatnik M.H., Hernandez-Sotomayor S.M., Jones G. et al. Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1994. — Vol. 91, no. 2. — P. 559—563. — doi:10.1073/pnas.91.2.559. — PMID 8290562. — PMC 42988.
Suzuki Y., Yoshitomo-Nakagawa K., Maruyama K. et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library (англ.) // Gene (англ.) (рус. : journal. — Elsevier, 1997. — Vol. 200, no. 1—2. — P. 149—156. — doi:10.1016/S0378-1119(97)00411-3. — PMID 9373149.
Liliental J., Chang D.D. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit (англ.) // J. Biol. Chem. : journal. — 1998. — Vol. 273, no. 4. — P. 2379—2383. — doi:10.1074/jbc.273.4.2379. — PMID 9442085.
Chang B.Y., Conroy K.B., Machleder E.M., Cartwright C.A. RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells (англ.) // Mol. Cell. Biol. (англ.) (рус. : journal. — 1998. — Vol. 18, no. 6. — P. 3245—3256. — PMID 9584165. — PMC 108906.
Rietzler M., Bittner M., Kolanus W. et al. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins (англ.) // J. Biol. Chem. : journal. — 1998. — Vol. 273, no. 42. — P. 27459—27466. — doi:10.1074/jbc.273.42.27459. — PMID 9765275.
Shimohama S., Kamiya S., Taniguchi T., Kimura J. Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease (англ.) // Alzheimer Disease and Associated Disorders (англ.) (рус. : journal. — 1999. — Vol. 12, no. 4. — P. 384—386. — doi:10.1097/00002093-199812000-00022. — PMID 9876970.
Yarwood S.J., Steele M.R., Scotland G. et al. The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform (англ.) // J. Biol. Chem. : journal. — 1999. — Vol. 274, no. 21. — P. 14909—14917. — doi:10.1074/jbc.274.21.14909. — PMID 10329691.
Ron D., Jiang Z., Yao L. et al. Coordinated movement of RACK1 with activated betaIIPKC (англ.) // J. Biol. Chem. : journal. — 1999. — Vol. 274, no. 38. — P. 27039—27046. — doi:10.1074/jbc.274.38.27039. — PMID 10480917.
Geijsen N., Spaargaren M., Raaijmakers J.A. et al. Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor (англ.) // Oncogene (англ.) (рус. : journal. — 1999. — Vol. 18, no. 36. — P. 5126—5130. — doi:10.1038/sj.onc.1202896. — PMID 10490850.
Smith P.R., de Jesus O., Turner D. et al. Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus (англ.) // J. Virol. (англ.) (рус. : journal. — 2000. — Vol. 74, no. 7. — P. 3082—3092. — doi:10.1128/JVI.74.7.3082-3092.2000. — PMID 10708423. — PMC 111807.
Ellis J.H., Ashman C., Burden M.N. et al. GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28 (англ.) // J. Immunol. (англ.) (рус. : journal. — 2000. — Vol. 164, no. 11. — P. 5805—5814. — doi:10.4049/jimmunol.164.11.5805. — PMID 10820259.
Croze E., Usacheva A., Asarnow D. et al. Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor (англ.) // J. Immunol. (англ.) (рус. : journal. — 2000. — Vol. 165, no. 9. — P. 5127—5132. — doi:10.4049/jimmunol.165.9.5127. — PMID 11046044.
Hartley J.L., Temple G.F., Brasch M.A. DNA cloning using in vitro site-specific recombination (англ.) // Genome Res. (англ.) (рус. : journal. — 2001. — Vol. 10, no. 11. — P. 1788—1795. — doi:10.1101/gr.143000. — PMID 11076863. — PMC 310948.

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Взаимодействия

Примечания

Литература