TACC2

TACC2

Identifiers

TACC2, AZU-1, ECTACC, transforming acidic coiled-coil containing protein 2

External IDs

OMIM: 605302; MGI: 1928899; HomoloGene: 5087; GeneCards: TACC2; OMA:TACC2 - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q26.13	Start	121,989,163 bp^[1]
Band	10q26.13	End	122,254,545 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 F3	Start	130,179,168 bp^[2]
Band	7\|7 F3	End	130,366,515 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

gastrocnemius muscle

skin of abdomen

body of tongue

left ventricle

right uterine tube

palpebral conjunctiva

bronchial epithelial cell

deltoid muscle

right ventricle

left lobe of thyroid gland

Top expressed in

digastric muscle

extraocular muscle

temporal muscle

triceps brachii muscle

sternocleidomastoid muscle

vastus lateralis muscle

soleus muscle

ankle

tibialis anterior muscle

right ventricle

More reference expression data

BioGPS


More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10579


57752

Ensembl


ENSG00000138162


ENSMUSG00000030852

UniProt


O95359 Q4VXL4


Q9JJG0

RefSeq (mRNA)

NM_001291876 NM_001291877 NM_001291878 NM_001291879 NM_006997
NM_206860 NM_206861 NM_206862


NM_001004468 NM_021314 NM_206856 NM_001347637

RefSeq (protein)

NP_001278805 NP_001278806 NP_001278807 NP_001278808 NP_008928
NP_996742 NP_996743 NP_996744 NP_001278808.1


NP_001004468 NP_001334566 NP_067289 NP_996738

Location (UCSC)

Chr 10: 121.99 – 122.25 Mb

Chr 7: 130.18 – 130.37 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Transforming acidic coiled-coil-containing protein 2 is a protein that in humans is encoded by the TACC2 gene.^[5]^[6]

Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is thought to affect the progression of breast tumors. Expression of this gene is also induced by erythropoietin.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138162 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030852 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gangisetty O, Lauffart B, Sondarva GV, Chelsea DM, Still IH (Apr 2004). "The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases". Oncogene. 23 (14): 2559–63. doi:10.1038/sj.onc.1207424. PMID 14767476. S2CID 22590391.
^ ^a ^b "Entrez Gene: TACC2 transforming, acidic coiled-coil containing protein 2".

Still IH, Vince P, Cowell JK (1999). "The third member of the transforming acidic coiled coil-containing gene family, TACC3, maps in 4p16, close to translocation breakpoints in multiple myeloma, and is upregulated in various cancer cell lines". Genomics. 58 (2): 165–70. doi:10.1006/geno.1999.5829. PMID 10366448.
Still IH, Hamilton M, Vince P, et al. (1999). "Cloning of TACC1, an embryonically expressed, potentially transforming coiled coil containing gene, from the 8p11 breast cancer amplicon". Oncogene. 18 (27): 4032–8. doi:10.1038/sj.onc.1202801. PMID 10435627.
Gergely F, Kidd D, Jeffers K, et al. (2000). "D–TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo". EMBO J. 19 (2): 241–52. doi:10.1093/emboj/19.2.241. PMC 305558. PMID 10637228.
Chen HM, Schmeichel KL, Mian IS, et al. (2000). "AZU-1: A Candidate Breast Tumor Suppressor and Biomarker for Tumor Progression". Mol. Biol. Cell. 11 (4): 1357–67. doi:10.1091/mbc.11.4.1357. PMC 14852. PMID 10749935.
Gergely F, Karlsson C, Still I, et al. (2001). "The TACC domain identifies a family of centrosomal proteins that can interact with microtubules". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14352–7. doi:10.1073/pnas.97.26.14352. PMC 18922. PMID 11121038.
Pu JJ, Li C, Rodriguez M, Banerjee D (2001). "Cloning and structural characterization of ECTACC, a new member of the transforming acidic coiled coil (TACC) gene family: cDNA sequence and expression analysis in human microvascular endothelial cells". Cytokine. 13 (3): 129–37. doi:10.1006/cyto.2000.0812. PMID 11161455.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lauffart B, Gangisetty O, Still IH (2003). "Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2". Genomics. 81 (2): 192–201. doi:10.1016/S0888-7543(02)00039-3. PMID 12620397.
Sadek CM, Pelto-Huikko M, Tujague M, et al. (2004). "TACC3 expression is tightly regulated during early differentiation". Gene Expr. Patterns. 3 (2): 203–11. doi:10.1016/S1567-133X(02)00066-2. PMID 12711550.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Still IH, Vettaikkorumakankauv AK, DiMatteo A, Liang P (2004). "Structure-function evolution of the Transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms". BMC Evol. Biol. 4: 16. doi:10.1186/1471-2148-4-16. PMC 441373. PMID 15207008.
Dou Z, Ding X, Zereshki A, et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323. S2CID 8403635.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

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This page was last edited on 29 November 2023, at 02:24

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References

Further reading