Rho gtpase activating protein 21

ARHGAP21

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2DHJ, 2J59, 2YUY

Identifiers

Aliases

ARHGAP21, ARHGAP10, Rho GTPase activating protein 21

External IDs

OMIM: 609870 MGI: 1918685 HomoloGene: 10822 GeneCards: ARHGAP21

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10p12.1\|10p12.3	Start	24,583,609 bp^[1]
Band	10p12.1\|10p12.3	End	24,723,668 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 A3	Start	20,852,730 bp^[2]
Band	2\|2 A3	End	20,973,692 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

Brodmann area 9

Achilles tendon

cingulate gyrus

stromal cell of endometrium

prefrontal cortex

amygdala

hypothalamus

corpus callosum

putamen

Top expressed in

lacrimal gland

cerebellar cortex

cerebellar vermis

parotid gland

secondary oocyte

subiculum

Region I of hippocampus proper

superior frontal gyrus

ankle joint

hippocampus proper

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	protein binding GTPase activator activity
Cellular component	Golgi apparatus Golgi membrane cytoplasmic vesicle membrane membrane cytoplasmic vesicle cytoplasm cytoskeleton cytosol plasma membrane actin cytoskeleton cell junction
Biological process	establishment of Golgi localization Golgi organization organelle transport along microtubule maintenance of Golgi location signal transduction positive regulation of GTPase activity regulation of small GTPase mediated signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


57584


71435

Ensembl


ENSG00000107863


ENSMUSG00000036591

UniProt


Q5T5U3


Q6DFV3

RefSeq (mRNA)


NM_020824


NM_001081364 NM_001128084

RefSeq (protein)

NP_065875 NP_001354376 NP_001354377 NP_001354378 NP_001354379
NP_001354380 NP_001354381 NP_001354382 NP_001354383 NP_001354384

NP_001074833 NP_001121556 NP_001395248 NP_001395249 NP_001395250
NP_001395251 NP_001395252 NP_001395253 NP_001395254

Location (UCSC)

Chr 10: 24.58 – 24.72 Mb

Chr 2: 20.85 – 20.97 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Rho GTPase activating protein 21 is a protein that in humans is encoded by the ARHGAP21 gene. ^[5]

Function

ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]). There is little scientific literature on ARHGAP21, but recent reviews highlighted that it plays an important role in cytoskeletal processes in cancer, substance transport within the cell, and insulin secretion ^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107863 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036591 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Rho GTPase activating protein 21". Retrieved 2017-01-30.
^ Rosa LRO; Soares, G. M.; Silveira, L. R.; Boschero, A. C.; Barbosa-Sampaio HCL (2018). "ARHGAP21 as a master regulator of multiple cellular processes". Journal of Cellular Physiology. 233 (11): 8477–8481. doi:10.1002/jcp.26829. PMID 29856495. S2CID 46919924.

Bassères DS, Tizzei EV, Duarte AA, Costa FF, Saad ST (2002). "ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein". Biochem. Biophys. Res. Commun. 294 (3): 579–85. doi:10.1016/S0006-291X(02)00514-4. PMID 12056806.
Dubois T, Paléotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M, Chavrier P (2005). "Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics". Nat. Cell Biol. 7 (4): 353–64. doi:10.1038/ncb1244. PMID 15793564. S2CID 37000096.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
Ménétrey J, Perderiset M, Cicolari J, Dubois T, Elkhatib N, El Khadali F, Franco M, Chavrier P, Houdusse A (2007). "Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes". EMBO J. 26 (7): 1953–62. doi:10.1038/sj.emboj.7601634. PMC 1847662. PMID 17347647.
Bigarella CL, Borges L, Costa FF, Saad ST (2009). "ARHGAP21 modulates FAK activity and impairs glioblastoma cell migration". Biochim. Biophys. Acta. 1793 (5): 806–16. doi:10.1016/j.bbamcr.2009.02.010. PMID 19268501.
Anthony DF, Sin YY, Vadrevu S, Advant N, Day JP, Byrne AM, Lynch MJ, Milligan G, Houslay MD, Baillie GS (2011). "β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation". Mol. Cell. Biol. 31 (5): 1066–75. doi:10.1128/MCB.00883-10. PMC 3067824. PMID 21173159.
Wang S, Li H, Chen Y, Wei H, Gao GF, Liu H, Huang S, Chen JL (2012). "Transport of influenza virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42 proteins". J. Biol. Chem. 287 (13): 9804–16. doi:10.1074/jbc.M111.312959. PMC 3323004. PMID 22318733.
Bigarella CL, Ferro KP, Barcellos KS, Martins-de-Souza D, Traina F, Novello JC, Saad ST, Archangelo LF (2012). "Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3". FEBS Lett. 586 (19): 3522–8. doi:10.1016/j.febslet.2012.08.012. PMID 22922005. S2CID 35663132.
Barcellos KS, Bigarella CL, Wagner MV, Vieira KP, Lazarini M, Langford PR, Machado-Neto JA, Call SG, Staley DM, Chung JY, Hansen MD, Saad ST (2013). "ARHGAP21 protein, a new partner of α-tubulin involved in cell-cell adhesion formation and essential for epithelial-mesenchymal transition". J. Biol. Chem. 288 (4): 2179–89. doi:10.1074/jbc.M112.432716. PMC 3554890. PMID 23235160.

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This page was last edited on 18 August 2023, at 08:58

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Function

References

Further reading