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Protein DEPP

From Wikipedia, the free encyclopedia

DEPP1

Identifiers

DEPP1, DEPP, FIG, Fseg, chromosome 10 open reading frame 10, autophagy regulator, C10orf10, DEPP1 autophagy regulator

External IDs

OMIM: 611309 MGI: 1918730 HomoloGene: 48491 GeneCards: DEPP1

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10q11.21	Start	44,970,981 bp^[1]
Band	10q11.21	End	44,978,809 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6\|6 E3	Start	116,627,570 bp^[2]
Band	6\|6 E3	End	116,629,755 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

pericardium

right lung

saphenous vein

gastric mucosa

vena cava

tibial nerve

right coronary artery

left uterine tube

popliteal artery

subcutaneous adipose tissue

Top expressed in

ciliary body

intercostal muscle

submandibular gland

retinal pigment epithelium

internal carotid artery

left lung lobe

external carotid artery

Region I of hippocampus proper

maxillary prominence

parotid gland

More reference expression data


More reference expression data

Species

Human

Mouse


11067


213393


ENSG00000165507


ENSMUSG00000048489


Q9NTK1


Q8K2F3

RefSeq (mRNA)


NM_007021


NM_001166580 NM_145980

RefSeq (protein)


NP_008952


NP_001160052 NP_666092

Location (UCSC)

Chr 10: 44.97 – 44.98 Mb

Chr 6: 116.63 – 116.63 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Protein DEPP also known as decidual protein induced by progesterone (DEPP) and fasting-induced gene protein (FIG) is a protein that in humans is encoded by the DEPP gene.^[5]

Function

The expression of this gene is induced by fasting as well as by progesterone. The protein encoded by this gene contains a t-synaptosome-associated protein receptor (SNARE) coiled-coil homology domain and a peroxisomal targeting signal. Production of the encoded protein leads to phosphorylation and activation of the transcription factor ELK1.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165507 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048489 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: C10orf10 chromosome 10 open reading frame 10".

Further reading

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Shin D, Anderson DJ (2005). "Isolation of arterial-specific genes by subtractive hybridization reveals molecular heterogeneity among arterial endothelial cells". Dev. Dyn. 233 (4): 1589–604. doi:10.1002/dvdy.20479. PMID 15977181. S2CID 20593942.
Watanabe H, Nonoguchi K, Sakurai T, et al. (2005). "A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor". Mol. Hum. Reprod. 11 (7): 471–6. doi:10.1093/molehr/gah186. PMID 16123073.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 17 October 2022, at 11:42

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