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Pildralazine

From Wikipedia, the free encyclopedia

Pildralazine
Clinical data
Other namesISF-2123
Routes of
administration		Oral
ATC code
  • None
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 1-[(6-Hydrazinylpyridazin-3-yl)(methyl)amino]propan-2-ol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC8H15N5O
Molar mass197.242 g·mol−1
3D model (JSmol)
  • n1nc(NN)ccc1N(C)CC(O)C
  • InChI=1S/C8H15N5O/c1-6(14)5-13(2)8-4-3-7(10-9)11-12-8/h3-4,6,14H,5,9H2,1-2H3,(H,10,11)
  • Key:KYIAWOXNPBANEW-UHFFFAOYSA-N

Pildralazine (Atensil), also known as propyldazine or propildazine, is an antihypertensive and vasodilator.[1]

Synthesis

Thieme Synthesis:[2] Patent:[3]

The reaction between 3,6-Dichloropyridazine [141-30-0] (1) and 1-(Methylamino)-2-propanol [16667-45-1] (2) gives CID:12237595 (3). Reaction with hydrazine completes the synthesis of Pidralazine (4).

References

  1. ^ Ganellin CR, Triggle DJ, Macdonald F (1997). Dictionary of pharmacological agents. CRC Press. p. 1603. ISBN 978-0-412-46630-4. Retrieved 25 November 2011.
  2. ^ Pifferi G, Parravicini F, Carpi C, Dorigotti L (July 1975). "Synthesis and antihypertensive properties of new 3-hydrazinopyridazine derivatives". Journal of Medicinal Chemistry. 18 (7): 741–746. doi:10.1021/jm00241a020. PMID 1151996.
  3. ^ DE2154245 idem G Pifferi, U.S. Patent 3,769,278 (1973 to Isf Spa).
This page was last edited on 1 April 2023, at 23:03
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