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Nebracetam

From Wikipedia, the free encyclopedia

Nebracetam
Clinical data
ATC code
  • none
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: Unscheduled Not FDA approved
Identifiers
  • (RS)-4-(Aminomethyl)-1-benzylpyrrolidin-2-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC12H16N2O
Molar mass204.273 g·mol−1
3D model (JSmol)
ChiralityRacemic mixture
  • O=C2N(Cc1ccccc1)CC(C2)CN
  • InChI=1S/C12H16N2O/c13-7-11-6-12(15)14(9-11)8-10-4-2-1-3-5-10/h1-5,11H,6-9,13H2 checkY
  • Key:LCAFGJGYCUMTGS-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Nebracetam is an investigational drug of the racetam family that is a M1 acetylcholine receptor agonist in rats.[1] Based on a human leukemic T cell experiment in 1991, it is believed to act as an agonist for human M1-muscarinic receptors.[2] It is also believed to act as a nootropic, like many other racetam drugs.[3] A chemoenzymatic method of synthesis was reported in 2008.[4] As of 2023, human trials have not yet been conducted.

See also

References

  1. ^ Takeo S, Hayashi H, Miyake K, Takagi K, Tadokoro M, Takagi N, Oshikawa S (June 1997). "Effects of delayed treatment with nebracetam on neurotransmitters in brain regions after microsphere embolism in rats". British Journal of Pharmacology. 121 (3): 477–84. doi:10.1038/sj.bjp.0701161. PMC 1564714. PMID 9179389.
  2. ^ Kitamura, Y.; Kaneda, T.; Nomura, Y. (January 1991). "Effects of nebracetam (WEB 1881 FU), a novel nootropic, as a M1-muscarinic agonist". Japanese Journal of Pharmacology. 55 (1): 177–180. doi:10.1254/jjp.55.177. ISSN 0021-5198. PMID 2041225.
  3. ^ Gabryel, B.; Pudełko, A.; Trzeciak, H. I.; Cieślik, P. (2000). "Effect of nebracetam on content of high-energy phosphates and morphometry of rat astrocytes in vitro. Comparison with piracetam". Acta Poloniae Pharmaceutica. 57 (4): 289–298. ISSN 0001-6837. PMID 11126618.
  4. ^ Yamashita, Sho; Mase, Nobuyuki; Takabe, Kunihiko (2008-09-22). "Chemoenzymatic total synthesis and determination of the absolute configuration of (S)-nebracetam". Tetrahedron: Asymmetry. 19 (18): 2115–2118. doi:10.1016/j.tetasy.2008.09.004. ISSN 0957-4166.
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This page was last edited on 11 December 2023, at 02:14
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