To install click the Add extension button. That's it.

The source code for the WIKI 2 extension is being checked by specialists of the Mozilla Foundation, Google, and Apple. You could also do it yourself at any point in time.

4,5
Kelly Slayton
Congratulations on this excellent venture… what a great idea!
Alexander Grigorievskiy
I use WIKI 2 every day and almost forgot how the original Wikipedia looks like.
Live Statistics
English Articles
Improved in 24 Hours
Added in 24 Hours
Languages
Recent
Show all languages
What we do. Every page goes through several hundred of perfecting techniques; in live mode. Quite the same Wikipedia. Just better.
.
Leo
Newton
Brights
Milds

Milbemycin oxime

From Wikipedia, the free encyclopedia

Milbemycin oxime
Clinical data
Trade namesInterceptor
License data
Routes of
administration
By mouth
ATCvet code
Legal status
Legal status
Pharmacokinetic data
Bioavailability5–10%
MetabolismLiver
ExcretionBile duct
Identifiers
CAS Number
UNII
ECHA InfoCard100.205.451 Edit this at Wikidata
Chemical and physical data
FormulaC31H43NO7 (30%)
C32H45NO7 (70%)
Molar mass541.68 g/mol (30%)
555.702 g/mol (70%)
 ☒NcheckY (what is this?)  (verify)

Milbemycin oxime, sold under the brand name Interceptor among others, is a veterinary medication from the group of milbemycins, used as a broad spectrum antiparasitic.[1] It is active against worms (anthelmintic)[1] and mites (miticide).[2]

Mechanism of action

Milbemycins are products of fermentation by Streptomyces species. They have a similar mechanism of action, but a longer half-life than the avermectins. Milbemycin oxime is produced by Streptomyces hygroscopicus aureolacrimosus. It opens glutamate sensitive chloride channels in neurons and myocytes of invertebrates, leading to hyperpolarisation of these cells and blocking of signal transfer.[3]

Uses

Milbemycin oxime is active against a broad spectrum of nematodes. Its miticide spectrum includes Sarcoptes and Demodex. The drug is FDA-approved for prevention of heartworm in dogs and cats,[4] although it is less potent against heartworms than ivermectin.[citation needed]

The substance is often combined with other parasiticides to achieve a broader spectrum of action. Such products include:[citation needed]

The drug has been used in marine reef aquaria to control parasitic Tegastidae copepod infestations on captive hard coral colonies. Other arthropod invertebrates will be killed by the treatment.[5][6]

Side effects

The drug is usually tolerated well, but such side effects may occur such as vomiting, phlegming, and glassy eyes.[citation needed]

References

  1. ^ a b c "Interceptor Flavor Tabs- milbemycin oxime tablet". DailyMed. Retrieved 4 August 2021.
  2. ^ Mueller, R. S. (2012). "An update on the therapy of canine demodicosis". Compendium (Yardley, Pa). 34 (4): E1-4. PMID 22488596.
  3. ^ Mehlhorn H (2008). Encyclopedia of Parasitology: A-M. Springer Science & Business Media. p. 646. ISBN 978-3-540-48994-8.
  4. ^ "NADA 140-915 Interceptor – supplemental approval (September 9, 1996)". Food and Drug Administration.
  5. ^ Roberts HE (2011). Fundamentals of Ornamental Fish Health. John Wiley & Sons. pp. 93–94. ISBN 978-1-119-94948-0.
  6. ^ Lewbart GA (2011). Invertebrate Medicine. John Wiley & Sons. p. 71. ISBN 978-0-470-96078-3.
This page was last edited on 23 February 2023, at 21:22
Basis of this page is in Wikipedia. Text is available under the CC BY-SA 3.0 Unported License. Non-text media are available under their specified licenses. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc. WIKI 2 is an independent company and has no affiliation with Wikimedia Foundation.