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Eprinomectin

From Wikipedia, the free encyclopedia

Eprinomectin B1a
Clinical data
Trade namesEprinex
Other namesMK-397, 4"-epi-acetylamino-4"-deoxy-avermectin B1a
(4"R)-4"-(acetylamino)-5-O-demethyl-4"-deoxyavermectin A1a
License data
Routes of
administration		Topical
ATCvet code
Legal status
Legal status
Pharmacokinetic data
Bioavailability29%[2]
Protein binding>99%[2]
Onset of action24 hours[2]
Elimination half-life8–36 days[2]
Duration of action7–10 days[2]
ExcretionFeces (17–19.8%), urine (0.35%), milk (0.32–0.54%)[2]
Identifiers
  • N-[(2S,3R,4S,6S)-6-[(2S,3S,4S,6R)-6-[(1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-2-[(2S)-butan-2-yl]-21',24'-dihydroxy-3,11',13',22'-tetramethyl-2'-oxospiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-12'-yl]oxy-4-methoxy-2-methyloxan-3-yl]oxy-4-methoxy-2-methyloxan-3-yl]acetamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC50H75NO14
Molar mass914.143 g·mol−1
3D model (JSmol)
  • CC[C@H](C)[C@@H]1[C@H](C=C[C@@]2(O1)C[C@@H]3C[C@H](O2)C/C=C(/[C@H]([C@H](/C=C/C=C/4\CO[C@H]5[C@@]4([C@@H](C=C([C@H]5O)C)C(=O)O3)O)C)O[C@H]6C[C@@H]([C@H]([C@@H](O6)C)O[C@H]7C[C@@H]([C@@H]([C@@H](O7)C)NC(=O)C)OC)OC)\C)C
  • InChI=1S/C50H75NO14/c1-12-26(2)45-29(5)18-19-49(65-45)24-36-21-35(64-49)17-16-28(4)44(27(3)14-13-15-34-25-58-47-43(53)30(6)20-37(48(54)61-36)50(34,47)55)62-41-23-39(57-11)46(32(8)60-41)63-40-22-38(56-10)42(31(7)59-40)51-33(9)52/h13-16,18-20,26-27,29,31-32,35-47,53,55H,12,17,21-25H2,1-11H3,(H,51,52)/b14-13+,28-16+,34-15+/t26-,27-,29-,31-,32-,35+,36-,37-,38-,39-,40-,41-,42+,43+,44-,45+,46-,47+,49+,50+/m0/s1
  • Key:ZKWQQXZUCOBISE-CRTGXIDZSA-N
Eprinomectin B1b
Clinical data
Other names4"-epi-acetylamino-4"-deoxy-avermectin B1b
ATC code
Identifiers
  • N-[(2S,3R,4S,6S)-6-[(2S,3S,4S,6R)-6-[(1'R,2R,3S,4'S,6S,8'R,10'E,12'S,13'S,14'E,16'E,20'R,21'R,24'S)-21',24'-dihydroxy-3,11',13',22'-tetramethyl-2'-oxo-2-propan-2-ylspiro[2,3-dihydropyran-6,6'-3,7,19-trioxatetracyclo[15.6.1.14,8.020,24]pentacosa-10,14,16,22-tetraene]-12'-yl]oxy-4-methoxy-2-methyloxan-3-yl]oxy-4-methoxy-2-methyloxan-3-yl]acetamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
FormulaC49H73NO14
Molar mass900.116 g·mol−1
3D model (JSmol)
  • C[C@H]1/C=C/C=C/2\CO[C@H]3[C@@]2([C@@H](C=C([C@H]3O)C)C(=O)O[C@H]4C[C@@H](C/C=C(/[C@H]1O[C@H]5C[C@@H]([C@H]([C@@H](O5)C)O[C@H]6C[C@@H]([C@@H]([C@@H](O6)C)NC(=O)C)OC)OC)\C)O[C@]7(C4)C=C[C@@H]([C@H](O7)C(C)C)C)O
  • InChI=1S/C49H73NO14/c1-25(2)43-28(5)17-18-48(64-43)23-35-20-34(63-48)16-15-27(4)44(26(3)13-12-14-33-24-57-46-42(52)29(6)19-36(47(53)60-35)49(33,46)54)61-40-22-38(56-11)45(31(8)59-40)62-39-21-37(55-10)41(30(7)58-39)50-32(9)51/h12-15,17-19,25-26,28,30-31,34-46,52,54H,16,20-24H2,1-11H3,(H,50,51)/b13-12+,27-15+,33-14+/t26-,28-,30-,31-,34+,35-,36-,37-,38-,39-,40-,41+,42+,43+,44-,45-,46+,48+,49+/m0/s1
  • Key:WPNHOHPRXXCPRA-FZTOWWROSA-N

Eprinomectin is an avermectin used as a veterinary topical endectocide.[1][3] It is a mixture of two chemical compounds, eprinomectin B1a and B1b.[4]

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Transcription

References

  1. ^ a b "Eprinex Pour-On For Beef And Dairy Cattle- eprinomectin solution". DailyMed. 28 February 2022. Retrieved 16 March 2023.
  2. ^ a b c d e f "Committee for Veterinary Medicinal Products: Eprinomectin" (PDF). The European Agency for the Evaluation of Medicinal Products. June 1996. Retrieved 2020-05-24.
  3. ^ Shoop WL, Egerton JR, Eary CH, Haines HW, Michael BF, Mrozik H, et al. (November 1996). "Eprinomectin: a novel avermectin for use as a topical endectocide for cattle". International Journal for Parasitology. 26 (11): 1237–42. doi:10.1016/s0020-7519(96)00123-3. PMID 9024867.
  4. ^ "UNII - 75KP30FD8O". U.S. Food and Drug Administration. Retrieved 16 March 2023.


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This page was last edited on 2 June 2023, at 08:21
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