MicroRNA 5008

MIR5008
Identifiers
Aliases	MIR5008, microRNA 5008
External IDs	GeneCards: MIR5008
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 227,941,590 bp[1] End 227,941,683 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in fundus blood muscle of leg gastrocnemius muscle placenta islet of Langerhans lymph node endometrium body of stomach left ventricle n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 100847072 n/a Ensembl ENSG00000264483 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 1: 227.94 – 227.94 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

MicroRNA 5008 is a protein that in humans is encoded by the MIR5008 gene.^[3]

Function

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. MiRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

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This page was last edited on 8 April 2022, at 19:41