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M62812

From Wikipedia, the free encyclopedia

M62812
Identifiers
  • 6-(2-aminophenoxy)-1,2-benzothiazol-3-amine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC13H11N3OS
Molar mass257.31 g·mol−1
3D model (JSmol)
  • C1=CC=C(C(=C1)N)OC2=CC3=C(C=C2)C(=NS3)N
  • InChI=1S/C13H11N3OS/c14-10-3-1-2-4-11(10)17-8-5-6-9-12(7-8)18-16-13(9)15/h1-7H,14H2,(H2,15,16)
  • Key:HQCTTYOADNAJJR-UHFFFAOYSA-N

M62812 is a drug which acts as a potent and selective antagonist of toll-like receptor 4 (TLR4). In animal studies it blocks TLR4-mediated cytokine release and has antiinflammatory effects, showing efficacy in animal models of arthritis and septic shock.[1][2]

See also

References

  1. ^ Nakamura M, Shimizu Y, Sato Y, Miyazaki Y, Satoh T, Mizuno M, et al. (August 2007). "Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice". European Journal of Pharmacology. 569 (3): 237–43. doi:10.1016/j.ejphar.2007.05.013. PMID 17588563.
  2. ^ Park H, Hong J, Yin Y, Joo Y, Kim Y, Shin J, et al. (October 2020). "TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model". Scientific Reports. 10 (1): 17451. Bibcode:2020NatSR..1017451P. doi:10.1038/s41598-020-74544-5. PMC 7567100. PMID 33060735.


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This page was last edited on 26 July 2023, at 23:56
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