IRF2BP2

IRF2BP2

Identifiers

IRF2BP2, interferon regulatory factor 2 binding protein 2, CVID14

External IDs

OMIM: 615332 MGI: 2443921 HomoloGene: 34290 GeneCards: IRF2BP2

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q42.3	Start	234,604,269 bp^[1]
Band	1q42.3	End	234,610,178 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 E2	Start	127,315,035 bp^[2]
Band	8\|8 E2	End	127,320,725 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

lactiferous duct

trachea

pancreatic epithelial cell

superior surface of tongue

pylorus

trigeminal ganglion

caput epididymis

nipple

pericardium

trabecular bone

Top expressed in

aortic valve

ascending aorta

molar

hand

left lung lobe

left colon

body of femur

foot

right lung lobe

lymph node

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	metal ion binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific
Cellular component	cytoplasm nucleus nucleoplasm
Biological process	transcription, DNA-templated regulation of transcription, DNA-templated immature B cell differentiation negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


359948


270110

Ensembl


ENSG00000168264


ENSMUSG00000051495

UniProt


Q7Z5L9


E9Q1P8

RefSeq (mRNA)


NM_182972 NM_001077397


NM_001164598

RefSeq (protein)


NP_001070865 NP_892017


NP_001158070

Location (UCSC)

Chr 1: 234.6 – 234.61 Mb

Chr 8: 127.32 – 127.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Interferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the IRF2BP2 gene. ^[5]

Function

This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168264 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051495 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Interferon regulatory factor 2 binding protein 2". Retrieved 2017-01-06.

Childs KS, Goodbourn S (2003). "Identification of novel co-repressor molecules for Interferon Regulatory Factor-2". Nucleic Acids Res. 31 (12): 3016–26. doi:10.1093/nar/gkg431. PMC 162335. PMID 12799427.
Tinnikov AA, Yeung KT, Das S, Samuels HH (2009). "Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells". Cancer Res. 69 (4): 1375–82. doi:10.1158/0008-5472.CAN-08-2896. PMC 4264605. PMID 19190336.
Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
Teng AC, Kuraitis D, Deeke SA, Ahmadi A, Dugan SG, Cheng BL, Crowson MG, Burgon PG, Suuronen EJ, Chen HH, Stewart AF (2010). "IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression". FASEB J. 24 (12): 4825–34. doi:10.1096/fj.10-167049. PMID 20702774. S2CID 35708173.
Carneiro FR, Ramalho-Oliveira R, Mognol GP, Viola JP (2011). "Interferon regulatory factor 2 binding protein 2 is a new NFAT1 partner and represses its transcriptional activity". Mol. Cell. Biol. 31 (14): 2889–901. doi:10.1128/MCB.00974-10. PMC 3133407. PMID 21576369.
Teng AC, Al-Montashiri NA, Cheng BL, Lou P, Ozmizrak P, Chen HH, Stewart AF (2011). "Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2". PLOS ONE. 6 (8): e24100. Bibcode:2011PLoSO...624100T. doi:10.1371/journal.pone.0024100. PMC 3162591. PMID 21887377.
Nyquist KB, Panagopoulos I, Thorsen J, Haugom L, Gorunova L, Bjerkehagen B, Fosså A, Guriby M, Nome T, Lothe RA, Skotheim RI, Heim S, Micci F (2012). "Whole-transcriptome sequencing identifies novel IRF2BP2-CDX1 fusion gene brought about by translocation t(1;5)(q42;q32) in mesenchymal chondrosarcoma". PLOS ONE. 7 (11): e49705. Bibcode:2012PLoSO...749705N. doi:10.1371/journal.pone.0049705. PMC 3504151. PMID 23185413.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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This page was last edited on 28 March 2024, at 01:57

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Function

References

Further reading