Hydroxyacid oxidase 2

HAO2
Identifiers
Aliases	HAO2, GIG16, HAOX2, hydroxyacid oxidase 2
External IDs	OMIM: 605176 MGI: 96012 HomoloGene: 97412 GeneCards: HAO2
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p12 Start 119,368,779 bp[1] End 119,394,130 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.2|3 42.9 cM Start 98,781,837 bp[2] End 98,800,555 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver kidney tubule kidney glomerulus metanephric glomerulus renal medulla vulva thymus nipple deltoid muscle Top expressed in left colon adrenal gland kidney proximal tubule adrenal medulla ileum cumulus cell ovary Paneth cell testicle More reference expression data BioGPS n/a
Gene ontology Molecular function (S)-2-hydroxy-acid oxidase activity oxidoreductase activity FMN binding signaling receptor binding catalytic activity Cellular component peroxisome peroxisomal matrix cytosol Biological process fatty acid oxidation fatty acid catabolic process protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51179 56185 Ensembl ENSG00000116882 ENSMUSG00000027870 UniProt Q9NYQ3 Q9NYQ2 RefSeq (mRNA) NM_001005783 NM_016527 NM_019545 RefSeq (protein) NP_001005783 NP_057611 NP_001364401 NP_062418 Location (UCSC) Chr 1: 119.37 – 119.39 Mb Chr 3: 98.78 – 98.8 Mb PubMed search [3] [4]
Wikidata
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Hydroxyacid oxidase 2 is a protein that in humans is encoded by the HAO2 gene. ^[5]

Function

This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

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This page was last edited on 8 April 2022, at 02:03