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Glutamate receptor delta-1 subunit also known as GluD1 or GluRδ1 is a transmembrane protein[5][6] (1009 aa) encoded by the GRID1 gene.[7][8] A C-terminal GluD1 splicing isoform (896 aa) has been described based on mRNA analysis.[9]
Several genetic epidemiology studies have shown a strong association between several variants of the GRID1 gene and increased risk of developing schizophrenia.[12][13]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yamazaki M, Araki K, Shibata A, Mishina M (March 1992). "Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family". Biochemical and Biophysical Research Communications. 183 (2): 886–92. doi:10.1016/0006-291X(92)90566-4. PMID1372507.
^Treadaway J, Zuo J (December 1998). "Mapping of the mouse glutamate receptor delta1 subunit (Grid1) to chromosome 14". Genomics. 54 (2): 359–60. doi:10.1006/geno.1998.5599. PMID9828146.
^Guo SZ, Huang K, Shi YY, Tang W, Zhou J, Feng GY, et al. (July 2007). "A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population". Schizophrenia Research. 93 (1–3): 385–90. doi:10.1016/j.schres.2007.03.007. PMID17490860. S2CID9497500.
^Treutlein J, Mühleisen TW, Frank J, Mattheisen M, Herms S, Ludwig KU, et al. (June 2009). "Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter". Schizophrenia Research. 111 (1–3): 123–30. doi:10.1016/j.schres.2009.03.011. PMID19346103. S2CID20949145.
This page was last edited on 13 August 2023, at 03:55