Excitatory amino acid transporter 4

SLC1A6

Identifiers

SLC1A6, EAAT4, solute carrier family 1 member 6

External IDs

OMIM: 600637; MGI: 1096331; HomoloGene: 21055; GeneCards: SLC1A6; OMA:SLC1A6 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19p13.12	Start	14,950,033 bp^[1]
Band	19p13.12	End	15,022,990 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10 C1\|10 39.72 cM	Start	78,616,330 bp^[2]
Band	10 C1\|10 39.72 cM	End	78,650,599 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

endothelial cell

cerebellar vermis

nucleus accumbens

oocyte

caudate nucleus

prefrontal cortex

putamen

sperm

cingulate gyrus

dorsolateral prefrontal cortex

Top expressed in

cerebellar vermis

dorsomedial hypothalamic nucleus

ventromedial nucleus

inferior colliculus

superior colliculus

lateral hypothalamus

ventral tegmental area

paraventricular nucleus of hypothalamus

dorsal tegmental nucleus

suprachiasmatic nucleus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	L-aspartate transmembrane transporter activity symporter activity L-glutamate transmembrane transporter activity amino acid transmembrane transporter activity high-affinity glutamate transmembrane transporter activity metal ion binding
Cellular component	integral component of membrane Golgi apparatus membrane intermediate filament cytoskeleton integral component of plasma membrane plasma membrane glutamatergic synapse integral component of presynaptic membrane
Biological process	chemical synaptic transmission regulation of membrane potential ion transport glutamate secretion aspartate transmembrane transport L-glutamate transmembrane transport L-glutamate import across plasma membrane amino acid transport L-aspartate transmembrane transport neurotransmitter uptake transmembrane transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


6511


20513

Ensembl


ENSG00000105143


ENSMUSG00000005357

UniProt


P48664


O35544

RefSeq (mRNA)

NM_001272087 NM_001272088 NM_005071 NM_001384669 NM_001384670
NM_001384671


NM_009200

RefSeq (protein)


NP_001259016 NP_001259017 NP_005062


NP_033226

Location (UCSC)

Chr 19: 14.95 – 15.02 Mb

Chr 10: 78.62 – 78.65 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene.^[5]^[6]

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105143 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005357 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)".
^ ^a ^b Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature. 375 (6532): 599–603. Bibcode:1995Natur.375..599F. doi:10.1038/375599a0. PMID 7791878. S2CID 4334983.

Deng X, Shibata H, Takeuchi N, et al. (2007). "Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (3): 271–8. doi:10.1002/ajmg.b.30351. PMID 17221839. S2CID 42347750.
Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis". Eur. J. Hum. Genet. 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMC 2986499. PMID 19156168.
Poulsen MV, Vandenberg RJ (2001). "Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4". J. Physiol. 534 (Pt 1): 159–67. doi:10.1111/j.1469-7793.2001.00159.x. PMC 2278676. PMID 11432999.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Koch HP, Brown RL, Larsson HP (2007). "The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits". J. Neurosci. 27 (11): 2943–7. doi:10.1523/JNEUROSCI.0118-07.2007. PMC 2435202. PMID 17360917.
Jackson M, Song W, Liu MY, et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins". Nature. 410 (6824): 89–93. doi:10.1038/35065091. PMID 11242047. S2CID 4381210.
Rajamanickam J, Palmada M, Lang F, Boehmer C (2007). "EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase". J. Neurochem. 102 (3): 858–66. doi:10.1111/j.1471-4159.2007.04585.x. PMID 17442044. S2CID 30779935.
Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824. S2CID 4420825.

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)

By group

SLC1–10

(1):	high affinity glutamate and neutral amino-acid transporter SLC1A1 2 3 4 5 6 7
(2):	facilitative GLUT transporter SLC2A1 2 3 4 5 6 7 8 9 10 11 12 13 14
(3):	heavy subunits of heterodimeric amino-acid transporters SLC3A1 2
(4):	bicarbonate transporter SLC4A1 2 3 4 5 6 7 8 9 10 11
(5):	sodium glucose cotransporter SLC5A1 2 3 4 5 6 7 8 9 10 11 12
(6):	sodium- and chloride- dependent sodium:neurotransmitter symporters SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 SLC6A10 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A16 SLC6A17 SLC6A18 SLC6A19 SLC6A20
(7):	cationic amino-acid transporter/glycoprotein-associated SLC7A1 SLC7A2 SLC7A3 SLC7A4 glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC7A10 SLC7A11 SLC7A13 SLC7A14
(8):	Na⁺/Ca²⁺ exchanger SLC8A1 SLC8A2 SLC8A3
(9):	Na⁺/H⁺ exchanger SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A10 SLC9A11
(10):	sodium bile salt cotransport SLC10A1 SLC10A2 SLC10A3 SLC10A4 SLC10A5 SLC10A6 SLC10A7 10A1 10A2 10A3 10A7

SLC11–20

(11):	proton coupled metal ion transporter SLC11A1 SLC11A2 11A3
(12):	electroneutral cation-Cl cotransporter SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC12A8 SLC12A9
(13):	human Na<sup>+</sup>-sulfate/carboxylate cotransporter SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5
(14):	urea transporter SLC14A1 SLC14A2
(15):	proton oligopeptide cotransporter SLC15A1 SLC15A2 SLC15A3 SLC15A4
(16):	monocarboxylate transporter SLC16A1 SLC16A2 SLC16A3 SLC16A4 SLC16A5 SLC16A6 SLC16A7 SLC16A8 SLC16A9 SLC16A10 SLC16A11 SLC16A12 SLC16A13 SLC16A14
(17):	Vesicular glutamate transporter 1 SLC17A1 SLC17A2 SLC17A3 SLC17A4 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC17A9
(18):	vesicular monoamine transporter SLC18A1 SLC18A2 SLC18A3
(19):	folate/thiamine transporter SLC19A1 SLC19A2 SLC19A3
(20):	type III Na⁺-phosphate cotransporter SLC20A1 SLC20A2

SLC21–30

(21):	Organic anion-transporting polypeptide SLCO1A2 SLCO1B1 SLCO1B3 SLCO1B4 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 SLCO5A1(SLCO6A1)
(22):	organic cation/anion/zwitterion transporter SLC22A1 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC22A9 SLC22A10 SLC22A11 SLC22A12 SLC22A13 SLC22A14 SLC22A15 SLC22A16 SLC22A17 SLC22A18 SLC22A19 SLC22A20
(23):	Na+-dependent ascorbic acid transporter SLC23A1 SLC23A2 SLC23A3 SLC23A4
(24):	Na⁺/(Ca²⁺-K⁺) exchanger SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC24A6
(25):	mitochondrial carrier SLC25A1 SLC25A2 SLC25A3 SLC25A4 SLC25A5 SLC25A6 SLC25A7 SLC25A8 SLC25A9 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC25A14 SLC25A15 SLC25A16 SLC25A17 SLC25A18 SLC25A19 SLC25A20 SLC25A21 SLC25A22 SLC25A23 SLC25A24 SLC25A25 SLC25A26 SLC25A27 SLC25A28 SLC25A29 SLC25A30 SLC25A31 SLC25A32 SLC25A33 SLC25A34 SLC25A35 SLC25A36 SLC25A37 SLC25A38 SLC25A39 SLC25A40 SLC25A41 SLC25A42 SLC25A43 SLC25A44 SLC25A45 SLC25A46
(26):	multifunctional anion exchanger SLC26A1 SLC26A2 SLC26A3 SLC26A4 SLC26A5 SLC26A6 SLC26A7 SLC26A8 SLC26A9 SLC26A10 SLC26A11
(27):	fatty acid transport proteins SLC27A1 SLC27A2 SLC27A3 SLC27A4 SLC27A5 SLC27A6
(28):	Na<sup>+</sup>-coupled nucleoside transport (SLC28A1 SLC28A2 SLC28A3
(29):	facilitative nucleoside transporter SLC29A1 SLC29A2 SLC29A3 SLC29A4
(30):	zinc efflux SLC30A1 SLC30A2 SLC30A3 SLC30A4 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC30A9 SLC30A10

SLC31–40

(31):	copper transporter SLC31A1
(32):	Vesicular glutamate transporter 1 SLC32A1
(33):	Acetyl-CoA transporter SLC33A1
(34):	type II Na<sup>+</sup>-phosphate cotransporter SLC34A1 SLC34A2 SLC34A3
(35):	nucleoside-sugar transporter SLC35A1 SLC35A2 SLC35A3 SLC35A4 SLC35A5 SLC35B1 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35C2 SLC35D1 SLC35D2 SLC35D3 SLC35E1 SLC35E2 SLC35E3 SLC35E4
(36):	proton-coupled amino-acid transporter SLC36A1 SLC36A2 SLC36A3 SLC36A436A2
(37):	sugar-phosphate/phosphate exchanger SLC37A1 SLC37A2 SLC37A3 SLC37A4
(38):	System A & N, sodium-coupled neutral amino-acid transporter SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC38A6 SLC38A10
(39):	metal ion transporter SLC39A1 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14
(40):	basolateral iron transporter SLC40A1

SLC41–48

(41):	Magnesium transporter E SLC41A1 SLC41A2 SLC41A3
(42):	Ammonia transporter RhAG RhBG RhCG
(43):	Na<sup>+</sup>-independent, system-L like amino-acid transporter SLC43A1 SLC43A2 SLC43A3
(44):	Choline-like transporter SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5
(45):	Putative sugar transporter SLC45A1 SLC45A2 SLC54A3 SLC45A4
(46):	Folate transporter SLC46A1 SLC46A2
(47):	multidrug and toxin extrusion SLC47A1 SLC47A2
(48):	Heme transporter

SLCO1–4
O1A2 O1B1 O1B3 O2B1 O431 O4A1

Ion pumps

Symporter, Cotransporter	Na⁺/K⁺,Cl⁻ Na⁺/P_i3 Na⁺/Cl⁻ Na⁺/glucose Na⁺/I⁻ Cl⁻/K⁺ 4 5
Antiporter (exchanger)	Na⁺/H⁺ Na⁺/Ca²⁺ Na⁺/(Ca²⁺-K⁺) - Cl⁻/HCO⁻ ₃ (Band 3) Cl⁻-formate Cl⁻-oxalate

see also solute carrier disorders

Glutamate metabolism and transport modulators

Transporter

EAATs

Amphetamine
Aspartic acid (aspartate)
cis-ACBD
DHKA
Glutamic acid (glutamate)
HIP-A
HIP-B
Kainic acid
L-(-)-threo-3-Hydroxyaspartic acid
L-αAA
L-CCG-III ((2S,3S,4R)-CCG)
L-Serine-O-sulphate (SOS)
L-trans-2,4-PDC
MPDC
Maslinic acid
SYM-2081
TBOA
TFB-TBOA
Theanine
threo-3-Methylglutamic acid
UCPH-101
WAY-213,613

vGluTs

4-Methylene-L-glutamate
6-(4'-Phenylstyryl)-QDC
6-Biphenyl-4-yl-QDC
7-CKA
Acid red 114
Amido black 10B (naphthol blue black)
Bafilomycin A1
Benzopurpurin 4B
Bumetamide
Chicago sky blue 6B
Aspartic acid (aspartate)
DIDS
Direct blue 71
Erythro-4-methyl-L-glutamic acid
Evans blue
Furosemide
Glutamic acid (glutamate)
Kynurenic acid
Nigericin
NPPB (N144)
Ponceau SS
Reactive blue 2
Rose bengal
SITS
trans-ACDP
Trypan blue
Valinomycin
Xanthurenic acid

Enzyme

GAHTooltip Glutamine aminohydrolase (glutaminase)	BPTES CB-839 DON
ASTTooltip Aspartate aminotransferase	2-Amino-3-butenoic acid AAOA AMB β-<span style="font-size:85%;">DL</span>-Methylene-aspartate Hydrazinosuccinate
ALTTooltip Alanine aminotransferase	β-Chloro-<span style="font-size:85%;">L</span>-alanine L-Cycloserine Propargylglycine
GDHTooltip Glutamate dehydrogenase	AAOA Bithionol Chloroquine EGCG GTP GW5074 Hexachlorophene Hydroxylamine Palmitoyl-CoA Pyridoxal phosphate
GSTooltip Glutamine synthetase	2-Aminoadipic acid JFD01307SC Methionine sulfoximine Phosphinothricin (glufosinate)
GADTooltip Glutamate decarboxylase	3-Mercaptopropionic acid AAOA L-Allylglycine Semicarbazide

See also: Receptor/signaling modulators • Ionotropic glutamate receptor modulators • Metabotropic glutamate receptor modulators • GABA metabolism and transport modulators

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This page was last edited on 29 March 2024, at 22:56

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References

Further reading