Dynein, axonemal, heavy chain 14

DNAH14
Identifiers
Aliases	DNAH14, C1orf67, Dnahc14, HL-18, HL18, dynein axonemal heavy chain 14
External IDs	OMIM: 603341 MGI: 2444525 HomoloGene: 90078 GeneCards: DNAH14
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.12 Start 224,896,262 bp[1] End 225,399,292 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4- H5 Start 181,404,124 bp[2] End 181,643,339 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas anterior pituitary islet of Langerhans right lobe of liver right uterine tube left lobe of thyroid gland ganglionic eminence right lobe of thyroid gland rectum body of stomach Top expressed in spermatocyte testicle bone marrow spermatid secondary oocyte thymus morula spleen pancreas islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule motor activity nucleotide binding cytoskeletal motor activity ATP binding minus-end-directed microtubule motor activity dynein light chain binding dynein intermediate chain binding dynein light intermediate chain binding Cellular component cytoplasm cell projection microtubule cytoskeleton cilium dynein complex Biological process microtubule-based movement cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 127602 240960 Ensembl ENSG00000185842 ENSMUSG00000047369 UniProt Q0VDD8 n/a RefSeq (mRNA) NM_001145154 NM_001373 NM_144989 NM_001349911 NM_001349912 NM_001367479 NM_001367481 NM_172846 NM_001377039 RefSeq (protein) NP_001138626 NP_659426 NP_001336840 NP_001336841 NP_001354408 NP_001354410 n/a Location (UCSC) Chr 1: 224.9 – 225.4 Mb Chr 1: 181.4 – 181.64 Mb PubMed search [3] [4]
Wikidata
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Dynein, axonemal, heavy chain 14 is a protein that in humans is encoded by the DNAH14 gene.^[5]

Function

Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).^[6]

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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This page was last edited on 16 April 2022, at 09:27