Disco interacting protein 2 homolog c

DIP2C

Identifiers

DIP2C, KIAA0934, disco interacting protein 2 homolog C

External IDs

OMIM: 611380; MGI: 1920179; HomoloGene: 40996; GeneCards: DIP2C; OMA:DIP2C - orthologs

Gene location (Human)

Chr.	Chromosome 10 (human)^[1]

Band	10p15.3	Start	274,190 bp^[1]
Band	10p15.3	End	689,668 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)^[2]

Band	13\|13 A1	Start	9,326,564 bp^[2]
Band	13\|13 A1	End	9,718,964 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

middle frontal gyrus

tibia

middle temporal gyrus

saphenous vein

quadriceps femoris muscle

vastus lateralis muscle

endothelial cell

Region I of hippocampus proper

deltoid muscle

kidney tubule

Top expressed in

facial motor nucleus

pontine nuclei

olfactory tubercle

amygdala

nucleus accumbens

superior cervical ganglion

substantia nigra

medial vestibular nucleus

anterior horn of spinal cord

subiculum

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	catalytic activity molecular function
Cellular component	cellular component
Biological process	metabolism biological process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


22982


208440

Ensembl


ENSG00000151240


ENSMUSG00000048264

UniProt


Q9Y2E4


n/a

RefSeq (mRNA)


NM_014974


NM_001081426 NM_172459

RefSeq (protein)


NP_055789


n/a

Location (UCSC)

Chr 10: 0.27 – 0.69 Mb

Chr 13: 9.33 – 9.72 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Disco interacting protein 2 homolog C is a protein that in humans is encoded by the DIP2C gene. ^[5]

Function

This gene encodes a member of the disco-interacting protein homolog 2 family. The protein shares strong similarity with a Drosophila protein which interacts with the transcription factor disco and is expressed in the nervous system. [provided by RefSeq, Oct 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151240 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048264 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Disco interacting protein 2 homolog C". Retrieved 2018-07-26.

Mukhopadhyay M, Pelka P, DeSousa D, Kablar B, Schindler A, Rudnicki MA, Campos AR (June 2002). "Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog". Gene. 293 (1–2): 59–65. doi:10.1016/s0378-1119(02)00694-7. PMID 12137943.
Oguri M, Kato K, Yokoi K, Yoshida T, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (January 2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
Yoshida T, Kato K, Yokoi K, Oguri M, Watanabe S, Metoki N, Yoshida H, Satoh K, Aoyagi Y, Nozawa Y, Yamada Y (April 2010). "Association of genetic variants with hemorrhagic stroke in Japanese individuals". Int. J. Mol. Med. 25 (4): 649–56. doi:10.3892/ijmm_00000388. PMID 20198315.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
Li WD, Jiao H, Wang K, Zhang CK, Glessner JT, Grant SF, Zhao H, Hakonarson H, Arlen Price R (September 2013). "A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls". Obesity (Silver Spring). 21 (9): E490–4. doi:10.1002/oby.20303. PMC 3762924. PMID 23703922.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 17 October 2022, at 11:08

From Wikipedia, the free encyclopedia

Function

References

Further reading