Chromatin target of prmt1

CHTOP

Identifiers

CHTOP, C1orf77, FL-SRAG, FOP, SRAG, SRAG-3, SRAG-5, pp7704, chromatin target of PRMT1, C10orf77

External IDs

OMIM: 614206 HomoloGene: 134556 GeneCards: CHTOP

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q21.3	Start	153,633,982 bp^[1]
Band	1q21.3	End	153,646,306 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

body of pancreas

right lobe of thyroid gland

left lobe of thyroid gland

canal of the cervix

gastrocnemius muscle

internal globus pallidus

cerebellar hemisphere

right uterine tube

body of stomach

n/a

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	methyl-CpG binding protein binding RNA binding
Cellular component	nuclear speck nucleolus transcription export complex nucleus nucleoplasm cytoplasmic ribonucleoprotein granule
Biological process	mRNA transport regulation of transcription, DNA-templated positive regulation of ATP-dependent activity positive regulation of helicase activity positive regulation of histone methylation transcription, DNA-templated positive regulation of cell population proliferation RNA export from nucleus termination of RNA polymerase II transcription mRNA export from nucleus mRNA 3'-end processing transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


26097


n/a

Ensembl


ENSG00000160679


n/a

UniProt


Q9Y3Y2


n/a

RefSeq (mRNA)


NM_001206612 NM_001244664 NM_015607 NM_001317077


n/a

RefSeq (protein)


NP_001193541 NP_001231593 NP_001304006 NP_056422


n/a

Location (UCSC)

Chr 1: 153.63 – 153.65 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Chromatin target of PRMT1 is a protein that in humans is encoded by the CHTOP gene.^[3]

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Transcription

Function

This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. The encoded protein may be involved in cell cycle progression. This protein interacts with protein arginine methyltransferases and plays a role in the activation of estradiol-dependent transcription. Alternate splicing results in multiple transcript variants.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160679 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Chromatin target of PRMT1".

Zullo AJ, Michaud M, Zhang W, Grusby MJ (May 2009). "Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation". The Journal of Biological Chemistry. 284 (18): 12504–11. doi:10.1074/jbc.M809436200. PMC 2673316. PMID 19254951.
Chang CT, Hautbergue GM, Walsh MJ, Viphakone N, van Dijk TB, Philipsen S, Wilson SA (February 2013). "Chtop is a component of the dynamic TREX mRNA export complex". The EMBO Journal. 32 (3): 473–86. doi:10.1038/emboj.2012.342. PMC 3567497. PMID 23299939.
Teng IF, Wilson SA (2013). "Mapping interactions between mRNA export factors in living cells". PLOS ONE. 8 (6): e67676. Bibcode:2013PLoSO...867676T. doi:10.1371/journal.pone.0067676. PMC 3691119. PMID 23826332.
van Dijk TB, Gillemans N, Stein C, Fanis P, Demmers J, van de Corput M, Essers J, Grosveld F, Bauer UM, Philipsen S (January 2010). "Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases". Molecular and Cellular Biology. 30 (1): 260–72. doi:10.1128/MCB.00645-09. PMC 2798285. PMID 19858291.
van Dijk TB, Gillemans N, Pourfarzad F, van Lom K, von Lindern M, Grosveld F, Philipsen S (November 2010). "Fetal globin expression is regulated by Friend of Prmt1". Blood. 116 (20): 4349–52. doi:10.1182/blood-2010-03-274399. PMC 2993632. PMID 20688955.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This page was last edited on 8 April 2022, at 01:22

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Transcription

Function

References

Further reading