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60S ribosomal protein L35a is a protein that in humans is encoded by the RPL35Agene.[5][6][7]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Transcript variants utilizing alternative transcription initiation sites and alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Feo S, Davies B, Fried M (Jun 1992). "The mapping of seven intron-containing ribosomal protein genes shows they are unlinked in the human genome". Genomics. 13 (1): 201–7. doi:10.1016/0888-7543(92)90221-D. PMID1577483.
^Colombo P, Read M, Fried M (Sep 1996). "The human L35a ribosomal protein (RPL35A) gene is located at chromosome band 3q29-qter". Genomics. 32 (1): 148–50. doi:10.1006/geno.1996.0093. PMID8786106.
Kroes RA, Jastrow A, McLone MG, et al. (2000). "The identification of novel therapeutic targets for the treatment of malignant brain tumors". Cancer Lett. 156 (2): 191–8. doi:10.1016/S0304-3835(00)00462-6. PMID10880769.
Lopez CD, Martinovsky G, Naumovski L (2002). "Inhibition of cell death by ribosomal protein L35a". Cancer Lett. 180 (2): 195–202. doi:10.1016/S0304-3835(02)00024-1. PMID12175552.
Kasai H, Nadano D, Hidaka E, et al. (2003). "Differential expression of ribosomal proteins in human normal and neoplastic colorectum". J. Histochem. Cytochem. 51 (5): 567–74. doi:10.1177/002215540305100502. PMID12704204. S2CID25865715.
This page was last edited on 9 January 2024, at 00:58