TNFRSF19

TNFRSF19

Identifiers

TNFRSF19, TAJ, TAJ-alpha, TRADE, TROY, tumor necrosis factor receptor superfamily member 19, TNF receptor superfamily member 19

External IDs

OMIM: 606122; MGI: 1352474; HomoloGene: 8481; GeneCards: TNFRSF19; OMA:TNFRSF19 - orthologs

Gene location (Human)

Chr.	Chromosome 13 (human)^[1]

Band	13q12.12	Start	23,570,370 bp^[1]
Band	13q12.12	End	23,676,104 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)^[2]

Band	14\|14 D1	Start	61,201,324 bp^[2]
Band	14\|14 D1	End	61,283,939 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bronchial epithelial cell

skin of abdomen

right uterine tube

trachea

stromal cell of endometrium

nipple

parotid gland

right ventricle

caput epididymis

vulva

Top expressed in

bronchus

calvaria

molar

main bronchus

body of femur

maxillary prominence

hair follicle

seminal vesicula

primitive streak

left lung lobe

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	tumor necrosis factor-activated receptor activity signaling receptor activity protein binding
Cellular component	integral component of membrane membrane intracellular anatomical structure plasma membrane
Biological process	hair follicle development JNK cascade apoptotic process positive regulation of JNK cascade tissue development positive regulation of I-kappaB kinase/NF-kappaB signaling tumor necrosis factor-mediated signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


55504


29820

Ensembl


ENSG00000127863


ENSMUSG00000060548

UniProt


Q9NS68


Q9JLL3

RefSeq (mRNA)


NM_001204458 NM_001204459 NM_018647 NM_148957 NM_001354985


NM_001164155 NM_013869

RefSeq (protein)


NP_001191387 NP_001191388 NP_061117 NP_683760 NP_001341914


NP_001157627 NP_038897

Location (UCSC)

Chr 13: 23.57 – 23.68 Mb

Chr 14: 61.2 – 61.28 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.^[5]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TNF receptor associated factor (TRAF) family members, and to activate c-Jun N-terminal kinases (JNK) signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.^[5]

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Transcription

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127863 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000060548 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: TNFRSF19 tumor necrosis factor receptor superfamily, member 19".

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Kojima T, Morikawa Y, Copeland NG, et al. (2000). "TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles". J. Biol. Chem. 275 (27): 20742–7. doi:10.1074/jbc.M002691200. PMID 10764796.
Eby MT, Jasmin A, Kumar A, et al. (2000). "TAJ, a novel member of the tumor necrosis factor receptor family, activates the c-Jun N-terminal kinase pathway and mediates caspase-independent cell death". J. Biol. Chem. 275 (20): 15336–42. doi:10.1074/jbc.275.20.15336. PMID 10809768.
Naito A, Yoshida H, Nishioka E, et al. (2002). "TRAF6-deficient mice display hypohidrotic ectodermal dysplasia". Proc. Natl. Acad. Sci. U.S.A. 99 (13): 8766–71. Bibcode:2002PNAS...99.8766N. doi:10.1073/pnas.132636999. PMC 124373. PMID 12060722.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Park JB, Yiu G, Kaneko S, et al. (2005). "A TNF receptor family member, TROY, is a coreceptor with Nogo receptor in mediating the inhibitory activity of myelin inhibitors". Neuron. 45 (3): 345–51. doi:10.1016/j.neuron.2004.12.040. PMID 15694321.
Shao Z, Browning JL, Lee X, et al. (2005). "TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration". Neuron. 45 (3): 353–9. doi:10.1016/j.neuron.2004.12.050. PMID 15694322.
Spanjaard RA, Whren KM, Graves C, Bhawan J (2007). "Tumor necrosis factor receptor superfamily member TROY is a novel melanoma biomarker and potential therapeutic target". Int. J. Cancer. 120 (6): 1304–10. doi:10.1002/ijc.22367. PMID 17187358.
Satoh J, Tabunoki H, Yamamura T, et al. (2007). "TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions". Neuropathol. Appl. Neurobiol. 33 (1): 99–107. doi:10.1111/j.1365-2990.2006.00787.x. PMID 17239012. S2CID 36762956.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cytokine receptors

Chemokine receptor
(GPCRs)

CC	CCR1 / CCRL1 CCR2 CCRL2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCR10
CXC	IL-8 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7
Other	CX3C CX3CR1 XC XCR1 CCBP2 CMKLR1

TNF receptor

1-10	TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) CD134 (TNFRSF4) CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8) CD137 (TNFRSF9)
11-20	DR4 (TNFRSF10A) DR5 (TNFRSF10B) DcR1 (TNFRSF10C) DcR2 (TNFRSF10D) RANK (TNFRSF11A) Osteoprotegerin (TNFRSF11B) TweakR (TNFRSF12A) TACI (TNFRSF13B) BAFFR (TNFRSF13C) HVEM (TNFRSF14) NGFR (TNFRSF16) BCMA (TNFRSF17) GITR (TNFRSF18) TAJ/TROY (TNFRSF19)
21-27	DR6 (TNFRSF21) DR3 (TNFRSF25) EDA2R (TNFRSF27)

JAK-STAT

Type I

γ-chain	Interleukin receptors IL2R / IL2RA/IL2RB / IL15R IL4R / IL13R / IL13RA1 / IL13RA2 IL7R / IL7RA IL9R IL21R
β-chain	Interleukin receptors IL3R / IL3RA IL5R / IL5RA GM-CSF
gp130	Interleukin receptors IL6RA 11/IL11RA 27/IL27RA OSMR LIFR CNTFR
IL12RB1	Interleukin receptors IL12R/IL12RB1/IL12RB2 IL23R23
Other	other CSF receptors EPO G-CSF Thrombopoietin hormone receptor: GH prolactin