CCR8 (gene)

CCR8

Identifiers

CCR8, CC-CKR-8, CCR-8, CDw198, CKRL1, CMKBR8, CMKBRL2, CY6, GPRCY6, TER1, C-C motif chemokine receptor 8

External IDs

OMIM: 601834 MGI: 1201402 HomoloGene: 21080 GeneCards: CCR8

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p22.1	Start	39,329,709 bp^[1]
Band	3p22.1	End	39,333,680 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 F4	Start	119,921,180 bp^[2]
Band	9\|9 F4	End	119,923,972 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

appendix

gallbladder

lymph node

blood

rectum

thymus

urinary bladder

spleen

lower respiratory tract

endometrium

Top expressed in

morula

pharynx

thymus

meninges

spleen

stomach

amygdala

thorax

limb

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	C-C chemokine receptor activity G protein-coupled receptor activity chemokine receptor activity coreceptor activity signal transducer activity chemokine binding C-C chemokine binding
Cellular component	integral component of membrane plasma membrane integral component of plasma membrane membrane intracellular anatomical structure external side of plasma membrane
Biological process	positive regulation of cytosolic calcium ion concentration chemotaxis chemokine-mediated signaling pathway G protein-coupled receptor signaling pathway cell adhesion immune response signal transduction calcium-mediated signaling cell chemotaxis
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1237


12776

Ensembl


ENSG00000179934


ENSMUSG00000042262

UniProt


P51685


P56484

RefSeq (mRNA)


NM_005201


NM_007720

RefSeq (protein)


NP_005192


NP_031746

Location (UCSC)

Chr 3: 39.33 – 39.33 Mb

Chr 9: 119.92 – 119.92 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Chemokine (C-C motif) receptor 8, also known as CCR8, is a protein which in humans is encoded by the CCR8 gene.^[5] CCR8 has also recently been designated CDw198 (cluster of differentiation w198).

Function

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. The ligand of the CCR8 is CCL1.^[6] CCL8 also functions as a CCR8 agonist.^[7]

Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000179934 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042262 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CCR8 chemokine (C-C motif) receptor 8".
^ Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW, Umland SP (October 1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332.
^ Islam SA, Chang DS, Colvin RA, Byrne MH, McCully ML, Moser B, Lira SA, Charo IF, Luster AD (2011). "Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells". Nat. Immunol. 12 (2): 167–77. doi:10.1038/ni.1984. PMC 3863381. PMID 21217759.

External links

Human CCR8 genome location and CCR8 gene details page in the UCSC Genome Browser.
"Chemokine Receptors: CCR8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2008-06-07. Retrieved 2008-12-03.

Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM (2004). "HIV-1 infection and chemokine receptor modulation". Curr. HIV Res. 2 (1): 39–50. doi:10.2174/1570162043484997. PMID 15053339.
Napolitano M, Zingoni A, Bernardini G, Spinetti G, Nista A, Storlazzi CT, Rocchi M, Santoni A (1996). "Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues". J. Immunol. 157 (7): 2759–63. doi:10.4049/jimmunol.157.7.2759. PMID 8816377.
Zaballos A, Varona R, Gutiérrez J, Lind P, Márquez G (1996). "Molecular cloning and RNA expression of two new human chemokine receptor-like genes". Biochem. Biophys. Res. Commun. 227 (3): 846–53. doi:10.1006/bbrc.1996.1595. PMID 8886020.
Samson M, Stordeur P, Labbé O, Soularue P, Vassart G, Parmentier M (1996). "Molecular cloning and chromosomal mapping of a novel human gene, ChemR1, expressed in T lymphocytes and polymorphonuclear cells and encoding a putative chemokine receptor". Eur. J. Immunol. 26 (12): 3021–8. doi:10.1002/eji.1830261230. PMID 8977299. S2CID 41090013.
Tiffany HL, Lautens LL, Gao JL, Pease J, Locati M, Combadiere C, Modi W, Bonner TI, Murphy PM (1997). "Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309". J. Exp. Med. 186 (1): 165–70. doi:10.1084/jem.186.1.165. PMC 2198957. PMID 9207005.
Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B (1997). "Identification of CCR8, the receptor for the human CC chemokine I-309". J. Biol. Chem. 272 (28): 17251–4. doi:10.1074/jbc.272.28.17251. PMID 9211859.
Horuk R, Hesselgesser J, Zhou Y, Faulds D, Halks-Miller M, Harvey S, Taub D, Samson M, Parmentier M, Rucker J, Doranz BJ, Doms RW (1998). "The CC chemokine I-309 inhibits CCR8-dependent infection by diverse HIV-1 strains". J. Biol. Chem. 273 (1): 386–91. doi:10.1074/jbc.273.1.386. PMID 9417093.
Goya I, Gutiérrez J, Varona R, Kremer L, Zaballos A, Márquez G (1998). "Identification of CCR8 as the specific receptor for the human beta-chemokine I-309: cloning and molecular characterization of murine CCR8 as the receptor for TCA-3". J. Immunol. 160 (4): 1975–81. doi:10.4049/jimmunol.160.4.1975. PMID 9469461.
Jinno A, Shimizu N, Soda Y, Haraguchi Y, Kitamura T, Hoshino H (1998). "Identification of the chemokine receptor TER1/CCR8 expressed in brain-derived cells and T cells as a new coreceptor for HIV-1 infection". Biochem. Biophys. Res. Commun. 243 (2): 497–502. doi:10.1006/bbrc.1998.8130. PMID 9480837.
Bernardini G, Hedrick J, Sozzani S, Luini W, Spinetti G, Weiss M, Menon S, Zlotnik A, Mantovani A, Santoni A, Napolitano M (1998). "Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor". Eur. J. Immunol. 28 (2): 582–8. doi:10.1002/(SICI)1521-4141(199802)28:02<582::AID-IMMU582>3.0.CO;2-A. PMID 9521068.
Zingoni A, Soto H, Hedrick JA, Stoppacciaro A, Storlazzi CT, Sinigaglia F, D'Ambrosio D, O'Garra A, Robinson D, Rocchi M, Santoni A, Zlotnik A, Napolitano M (1998). "The chemokine receptor CCR8 is preferentially expressed in Th2 but not Th1 cells". J. Immunol. 161 (2): 547–51. doi:10.4049/jimmunol.161.2.547. PMID 9670926.
Efremov R, Truong MJ, Darcissac EC, Zeng J, Grau O, Vergoten G, Debard C, Capron A, Bahr GM (1999). "Human chemokine receptors CCR5, CCR3 and CCR2B share common polarity motif in the first extracellular loop with other human G-protein coupled receptors implications for HIV-1 coreceptor function". Eur. J. Biochem. 263 (3): 746–56. doi:10.1046/j.1432-1327.1999.00553.x. PMID 10469138.
Garlisi CG, Xiao H, Tian F, Hedrick JA, Billah MM, Egan RW, Umland SP (1999). "The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". Eur. J. Immunol. 29 (10): 3210–5. doi:10.1002/(SICI)1521-4141(199910)29:10<3210::AID-IMMU3210>3.0.CO;2-W. PMID 10540332.
Lee S, Tiffany HL, King L, Murphy PM, Golding H, Zaitseva MB (2000). "CCR8 on human thymocytes functions as a human immunodeficiency virus type 1 coreceptor". J. Virol. 74 (15): 6946–52. doi:10.1128/JVI.74.15.6946-6952.2000. PMC 112211. PMID 10888633.
Howard OM, Dong HF, Shirakawa AK, Oppenheim JJ (2000). "LEC induces chemotaxis and adhesion by interacting with CCR1 and CCR8". Blood. 96 (3): 840–5. doi:10.1182/blood.V96.3.840. PMID 10910894.
Rosu-Myles M, Khandaker M, Wu DM, Keeney M, Foley SR, Howson-Jan K, Yee IC, Fellows F, Kelvin D, Bhatia M (2000). "Characterization of chemokine receptors expressed in primitive blood cells during human hematopoietic ontogeny". Stem Cells. 18 (5): 374–81. doi:10.1634/stemcells.18-5-374. PMID 11007922. S2CID 24126030.
Utaipat U, Duerr A, Rudolph DL, Yang C, Butera ST, Lupo D, Pisell T, Tangmunkongvorakul A, Kamtorn N, Nantachit N, Nagachinta T, Suriyanon V, Robison V, Nelson KE, Sittisombut N, Lal RB (2002). "Coreceptor utilization of HIV type 1 subtype E viral isolates from Thai men with HIV type 1-infected and uninfected wives". AIDS Res. Hum. Retroviruses. 18 (1): 1–11. doi:10.1089/088922202753394664. PMID 11804551.
Annunziato F, Cosmi L, Liotta F, Lazzeri E, Manetti R, Vanini V, Romagnani P, Maggi E, Romagnani S (2002). "Phenotype, localization, and mechanism of suppression of CD4(+)CD25(+) human thymocytes". J. Exp. Med. 196 (3): 379–87. doi:10.1084/jem.20020110. PMC 2193942. PMID 12163566.
Spinetti G, Bernardini G, Camarda G, Mangoni A, Santoni A, Capogrossi MC, Napolitano M (2003). "The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK-dependent pathway". J. Leukoc. Biol. 73 (1): 201–7. doi:10.1189/jlb.0302105. PMID 12525579. S2CID 25301611.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cytokine receptors

Chemokine receptor
(GPCRs)

CC	CCR1 / CCRL1 CCR2 CCRL2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9 CCR10
CXC	IL-8 CXCR1 CXCR2 CXCR3 CXCR4 CXCR5 CXCR6 CXCR7
Other	CX3C CX3CR1 XC XCR1 CCBP2 CMKLR1

TNF receptor

1-10	TNFR1 (TNFRSF1A) TNFR2 (TNFRSF1B) LTBR (TNFRSF3) CD134 (TNFRSF4) CD40 (TNFRSF5) Fas receptor (TNFRSF6) DcR3 (TNFRSF6B) CD27 (TNFRSF7) CD30 (TNFRSF8) CD137 (TNFRSF9)
11-20	DR4 (TNFRSF10A) DR5 (TNFRSF10B) DcR1 (TNFRSF10C) DcR2 (TNFRSF10D) RANK (TNFRSF11A) Osteoprotegerin (TNFRSF11B) TweakR (TNFRSF12A) TACI (TNFRSF13B) BAFFR (TNFRSF13C) HVEM (TNFRSF14) NGFR (TNFRSF16) BCMA (TNFRSF17) GITR (TNFRSF18) TAJ/TROY (TNFRSF19)
21-27	DR6 (TNFRSF21) DR3 (TNFRSF25) EDA2R (TNFRSF27)

JAK-STAT

Type I

γ-chain	Interleukin receptors IL2R / IL2RA/IL2RB / IL15R IL4R / IL13R / IL13RA1 / IL13RA2 IL7R / IL7RA IL9R IL21R
β-chain	Interleukin receptors IL3R / IL3RA IL5R / IL5RA GM-CSF
gp130	Interleukin receptors IL6RA 11/IL11RA 27/IL27RA OSMR LIFR CNTFR
IL12RB1	Interleukin receptors IL12R/IL12RB1/IL12RB2 IL23R23
Other	other CSF receptors EPO G-CSF Thrombopoietin hormone receptor: GH prolactin

Type II

Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2

Ig superfamily

IL1
- IL1R1
- IL1R2
IL18R / IL18R1

IL 17 family

IL17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE

Enzyme-linked receptor

Tyr
- CSF1R
- KIT
Ser/Thr: TGF-beta
- TGFBR1
- TGFBR2
- family

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

Chemokine receptor modulators

CCR1	Agonists: CCL4 (MIP-1β) CCL5 (RANTES) CCL6 CCL9 (CCL10) CCL14 CCL15 CCL16 CCL23
CCR2	Agonists: CCL2 CCL8 CCL12 CCL16 NAMs: Cenicriviroc (TAK-652, TBR-652)
CCR3	Agonists: CCL5 (RANTES) CCL7 CCL11 CCL13 CCL15 CCL18 CCL24 CCL26 CCL28
CCR4	Agonists: CCL3 (MIP-1α) CCL5 (RANTES) CCL17 CCL22 Antibodies: Mogamulizumab (against CCR4)
CCR5	Agonists: CCL3 (MIP-1α) CCL4 (MIP-1β) CCL5 (RANTES) CCL8 CCL11 CCL13 CCL14 CCL16 NAMs: Aplaviroc Cenicriviroc (TAK-652, TBR-652) INCB009471 Maraviroc Vicriviroc Antibodies: PRO-140
CCR6	Agonists: CCL20
CCR7	Agonists: CCL19 CCL21
CCR8	Agonists: CCL1 CCL16
CCR9	Agonists: CCL25
CCR10	Agonists: CCL27 CCL28
CCR11	Agonists: CCL19 CCL21 CCL25
Ungrouped	Antibodies: Bertilimumab (against CCL11) Carlumab (against CCL2)

CXC

CXCR1 (IL-8Rα)	Agonists: CXCL6 Emoctakin Interleukin-8 (CXCL8, GCP-1) Antagonists: Navarixin NAMs: Ladarixin Reparixin (repertaxin)
CXCR2 (IL-8Rβ)	Agonists: CXCL1 (MGSA) CXCL2 CXCL3 CXCL5 CXCL6 CXCL7 Emoctakin Garnocestim Interleukin-8 (CXCL8, GCP-1) Antagonists: Danirixin Elubrixin Navarixin NAMs: Ladarixin Reparixin (repertaxin)
CXCR3	Agonists: CXCL4 (PF4) CXCL9 (MIG) CXCL10 (IP-10) CXCL11 (I-TAC) Iroplact Antibodies: Eldelumab (against CXCL10)
CXCR4	Agonists: MIF SDF-1 (CXCL12) Ubiquitin Antagonists: Mavorixafor Plerixafor (AMD3100) Antibodies: Ulocuplumab (against CXCR4)
CXCR5	Agonists: CXCL13
CXCR6	Agonists: CXCL16
CXCR7	Agonists: CXCL11 (I-TAC) SDF-1 (CXCL12) PAMs: Plerixafor (AMD3100)

C (XC)

XCR1	Agonists: Lymphotactin-α (XCL1) Lymphotactin-β (XCL2) Antibodies: Pateclizumab

CX3C

CX3CR1	Agonists: Fractalkine (CX3CL1)

Others

CCBP2	Agonists: CC (β) chemokines
CMKLR1	Agonists: Chemerin Resolvin E1

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Function

See also

References

External links

Further reading