SNTG1

SNTG1

Identifiers

SNTG1, G1SYN, SYN4, syntrophin gamma 1

External IDs

OMIM: 608714 MGI: 1918346 HomoloGene: 56834 GeneCards: SNTG1

Gene location (Human)

Chr.	Chromosome 8 (human)^[1]

Band	8q11.21	Start	49,909,789 bp^[1]
Band	8q11.21	End	50,796,692 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 A1-A2	Start	8,361,475 bp^[2]
Band	1\|1 A1-A2	End	9,299,878 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Brodmann area 23

middle temporal gyrus

dorsolateral prefrontal cortex

Brodmann area 9

nucleus accumbens

prefrontal cortex

caudate nucleus

superior frontal gyrus

putamen

postcentral gyrus

Top expressed in

spermatid

superior frontal gyrus

facial motor nucleus

cerebellar cortex

hippocampus proper

seminiferous tubule

primary motor cortex

mesencephalon

anterior horn of spinal cord

neural tube

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	actin binding protein C-terminus binding structural molecule activity
Cellular component	cytoplasm ruffle membrane syntrophin complex cytoskeleton nucleus dystrophin-associated glycoprotein complex
Biological process	cell communication
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


54212


71096

Ensembl


ENSG00000147481


ENSMUSG00000025909

UniProt


Q9NSN8


Q925E1

RefSeq (mRNA)

NM_001287813 NM_001287814 NM_018967 NM_001321773 NM_001321775
NM_001321776 NM_001321777 NM_001321778


NM_001290390 NM_001290392 NM_001290393 NM_027671

RefSeq (protein)

NP_001274742 NP_001274743 NP_001308702 NP_001308704 NP_001308705
NP_001308706 NP_001308707 NP_061840 NP_001274742.1 NP_061840.1 NP_001308702.1


NP_001277319 NP_001277321 NP_001277322 NP_081947

Location (UCSC)

Chr 8: 49.91 – 50.8 Mb

Chr 1: 8.36 – 9.3 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.^[5]^[6]

The protein encoded by this gene is a member of the syntrophin family. Syntrophins are cytoplasmic peripheral membrane proteins that typically contain 2 pleckstrin homology (PH) domains, a PDZ domain that bisects the first PH domain, and a C-terminal domain that mediates dystrophin binding. This gene is specifically expressed in the brain. Transcript variants for this gene have been described, but their full-length nature has not been determined.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147481 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025909 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Piluso G, Mirabella M, Ricci E, Belsito A, Abbondanza C, Servidei S, Puca AA, Tonali P, Puca GA, Nigro V (Jun 2000). "Gamma1- and gamma2-syntrophins, two novel dystrophin-binding proteins localized in neuronal cells". J Biol Chem. 275 (21): 15851–60. doi:10.1074/jbc.M000439200. PMID 10747910.
^ ^a ^b "Entrez Gene: SNTG1 syntrophin, gamma 1".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Hogan A, Shepherd L, Chabot J, et al. (2001). "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions". J. Biol. Chem. 276 (28): 26526–33. doi:10.1074/jbc.M104156200. PMID 11352924.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Widberg CH, Bryant NJ, Girotti M, et al. (2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". J. Biol. Chem. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
Buxton P, Zhang XM, Walsh B, et al. (2004). "Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells". Biochem. J. 375 (Pt 2): 433–40. doi:10.1042/BJ20030427. PMC 1223698. PMID 12877659.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Chen Z, Hague C, Hall RA, Minneman KP (2006). "Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction". J. Biol. Chem. 281 (18): 12414–20. doi:10.1074/jbc.M508651200. PMID 16533813.

Membrane/
extracellular

DAP:	Sarcoglycan SGCA SGCB SGCD SGCE SGCG SGCZ Dystroglycan
Sarcospan Laminin, alpha 2

Intracellular

Dystrophin Dystrobrevin A B Syntrophin A B1 B2 G1 G2 Syncoilin Dysbindin Synemin/desmuslin
related:	NOS1 Caveolin 3

Sarcomere/
(a, i, and h bands;
z and m lines)

Myofilament

Tropomyosin

Troponin
- T
- C
- I

Connective tissue

General

Cardiac
muscle

Both

Fiber	Muscle fiber intrafusal extrafusal Myofibril Microfilament/Myofilament Sarcomere
Cells	Myoblast/Muscle cell Myosatellite cell
Other	Desmin Sarcoplasm Sarcolemma T-tubule Sarcoplasmic reticulum

Other/
ungrouped

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This page was last edited on 13 October 2022, at 17:42

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References

Further reading