Methylenation

In organic chemistry, methylenation is a chemical reaction that inserts a methylene (−CH₂−) group into a chemical compound:

{\ce {A-B}}\longrightarrow {\ce {A}}{\color {red}{\ce {-CH2 -}}}{\ce {B}}

In a related sense, it also describes a process in which a divalent group of a starting material is removed and replaced with a terminal CH₂ group:

{\ce {A=E}}\longrightarrow {\ce {A}}{\color {red}{\ce {=CH2}}}

Methylenation in this context is also known as methenylation. Most commonly, E is an oxygen atom, so that the reaction results in terminal alkenes from aldehydes and ketones, or more rarely, enol ethers from esters or enamines from amides.

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Methods

Methylene Insertion into Alkanes

Singlet methylene (¹[:CH₂]), produced from photolysis of diazomethane under ultraviolet irradiation,^[1] methylenates hydrocarbons. Arenes and olefins undergo methylenation to give cyclopropanated products. In the case of arenes, the cyclopropanation product undergoes further electrocyclic ring opening to give cycloheptatriene products (Buchner ring expansion).^[2] Alkenes undergo both C=C methylenation and C–H methylenation insertion to give a mixture of cyclopropanation and homologation products.

Reflecting the exceptionally high reactivity of singlet methylene, normally unreactive alkanes undergo methylenation to give homologation products, even at –75 °C.^[3]

{\ce {R-H}}+{\color {red}{\ce {CH2}}}\longrightarrow {\ce {R}}{\color {red}{\ce {-CH2}}}{\ce {H}}

Photolysis of a solution of diazomethane in n-pentane gives a mixture of hexanes and higher homologues. At –75 °C, the product ratio is 48:35:17 mixture of n-hexane, 2-methylpentane, and 3-methylpentane. The ratio is remarkably close to the statistical product ratio of 6:4:2 (~50:33:17) based on the number of available C–H bonds at each position that could undergo methylene insertion. As a result, Doering and coworkers concluded:

Methylene must be classed as the most indiscriminate reagent known in organic chemistry.

Methylene-for-oxo reactions

A common method for methylenation involves the Wittig reaction using methylenetriphenylphosphorane with an aldehyde (Ph = phenyl, C₆H₅):^[4]

{\ce {RCHO + Ph3P=CH2 -> RCH=CH2 + Ph3PO}}

A related reaction can be accomplished with Tebbe's reagent, which is sufficiently versatile to allow methylenation of esters:^[5]

{\ce {RCO2R' + Cp2Ti(Cl)CH2AlMe2 -> RC(OR')=CH2 + Cp2TiOAlMe2Cl}}

Other less well-defined titanium reagents, e.g., Lombardo's reagent, effect similar transformations.^[6]^[7]

Carbanions derived from methylsulfones have also been employed, equivalently to the Wittig reaction.^[8]

Methylenation adjacent to carbonyl groups

Ketones and esters can be methylenated at the α position to give α,β-unsaturated carbonyl products containing an additional terminal CH₂ group in a three-step process known as the Eschenmoser methylenation.^[9] An enolate is generated by deprotonation of the α-C–H bond using a hindered lithium amide (LiNR₂) base (e.g., LDA, LHMDS). Subsequently, the enolate is reacted with Eschenmoser's salt ([Me₂N=CH₂]⁺I^–) to give a β-dimethylamino carbonyl compound (Mannich base). The Mannich base is then subjected to methylation or N-oxidation to give a trimethylammonium salt or amine N-oxide, which is then subjected to Hofmann elimination or Cope elimination, respectively to give the α-methylene carbonyl compound. If the Hofmann elimination is used, the process can be represented as follows:

{\ce {RC(=O)CH2R' -> RC(=O) CH(CH2NMe2)R' -> [RC(=O) CH(CH2NMe3)R']+I- -> RC(=O) C(=CH2)(R')}}

Other approaches

Ethenolysis is a method for methylenation of internal alkene as illustrated by the following example:

{\ce {RCH=CHR}}+{\color {red}{\ce {CH2=CH2}}}\longrightarrow {\ce {2 RCH=}}{\color {red}{\ce {CH2}}}

In principle, the addition of CH₂ across a C=C double bond could be classified as a methylenation, but such transformations are commonly described as cyclopropanations.

References

^ Braun, W.; Bass, Arnold M.; Pilling, M. (1970-05-15). "Flash Photolysis of Ketene and Diazomethane: The Production and Reaction Kinetics of Triplet and Singlet Methylene". The Journal of Chemical Physics. 52 (10): 5131–5143. doi:10.1063/1.1672751. ISSN 0021-9606.
^ Winberg, H (1959). "Notes- Synthesis of Cycloheptatriene". The Journal of Organic Chemistry. 24 (2): 264–265. doi:10.1021/jo01084a635. ISSN 0022-3263.
^ von E. Doering, W.; Buttery, R. G.; Laughlin, R. G.; Chaudhuri, N. (1956). "INDISCRIMINATE REACTION OF METHYLENE WITH THE CARBON-HYDROGEN BOND". Journal of the American Chemical Society. 78 (13): 3224–3224. doi:10.1021/ja01594a071. ISSN 0002-7863.
^ Eric J. Leopold (1986). "Selective Hydroboration of a 1,3,7-Triene: Homogeraniol". Organic Syntheses. 64: 164. doi:10.15227/orgsyn.064.0164.
^ Straus, Daniel A.; Morshed, M. Monzur; Dudley, Matthew E.; Hossain, M. Mahmun (2006). "μ-Chlorobis(cyclopentadienyl)(dimethylaluminium)-μ-methylenetitanium". Encyclopedia of Reagents for Organic Synthesis. doi:10.1002/047084289X.rc073.pub2. ISBN 0471936235.
^ Luciano Lombardo (1987). "Methylenation of Carbonyl Compounds: (+)-3-Methylene-cis-p-menthane". Organic Syntheses. 65: 81. doi:10.15227/orgsyn.065.0081.
^ Marsden, Stephen P; Ducept, Pascal C (2005). "Synthesis of highly substituted allenylsilanes by alkylidenation of silylketenes". Beilstein Journal of Organic Chemistry. 1 (1): 5. doi:10.1186/1860-5397-1-5. PMC 1399453. PMID 16542018.
^ Ando, Kaori; Oguchi, Mai; Kobayashi, Takahisa; Asano, Haruka; Uchida, Nariaki (2020). "Methylenation for Aldehydes and Ketones Using 1-Methylbenzimidazol-2-yl Methyl Sulfone". The Journal of Organic Chemistry. 85 (15): 9936–9943. doi:10.1021/acs.joc.0c01227. PMID 32608238.
^ Schreiber, Jakob; Maag, Hans; Hashimoto, Naoto; Eschenmoser, Albert (1971). "Dimethyl(methylene)ammonium Iodide". Angewandte Chemie International Edition in English. 10 (5): 330–331. doi:10.1002/anie.197103301. ISSN 0570-0833.

This page was last edited on 13 April 2024, at 07:05

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