Lupus vulgaris (also known as tuberculosis luposa[1]) are painful cutaneous tuberculosis skin lesions with nodular appearance, most often on the face around the nose, eyelids, lips, cheeks, ears[2] and neck. It is the most common Mycobacterium tuberculosis skin infection.[3] The lesions may ultimately develop into disfiguring skin ulcers if left untreated.
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Transcription
Signs and symptoms
It begins as painless reddish-brown nodules which slowly enlarge to form irregularly shaped red plaque.[3]
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Lupus vulgaris, changes in skin in hyperkeratotic forms -
Lupus vulgaris in a woman, late 19th century -
Lupus vulgaris in a man, c. 1900 -
Advanced lupus vulgaris over the entire face and neck
Cause
Lupus vulgaris often develops due to inadequately treated pre-existing tuberculosis.[3] It may also develop at site of BCG vaccination.[4] Rarely, it has been shown to be associated with tattoo marks.[5]
Histopathology
Histologically, it shows presence of epithelioid cell granulomas with Langhans giant cells with or without central caseation necrosis in the dermis.[6]
Diagnosis
On diascopy, it shows characteristic "apple-jelly" color. Biopsy will reveal tuberculoid granuloma with few bacilli. Mantoux test is positive.
Differential diagnosis
The condition should be distinguished from:
- Basal-cell carcinoma[3]
- Sarcoidosis[3]
- Discoid lupus erythomatosus[3]
- Leprosy[4]
- Deep fungal infection[4]
Management
A dermatologist or general physician usually administers combination therapy of drugs used for tuberculosis, such as rifampicin, isoniazid, and pyrazinamide (possibly with either streptomycin or ethambutol).[3]
Prognosis
In longstanding scarred lesions, squamous-cell carcinoma can develop.[3]
History
In the 19th century, the chronic and progressive nature of this disease was particularly marked: it remained active for ten years, twenty years, or even longer and, proved resistant to all treatment until the breakthrough by Niels Ryberg Finsen using a form of "concentrated light radiation" or light therapy (now known as photobiomodulation) which won him a Nobel Prize.
The inscription on a bronze statue of Queen Alexandra of Great Britain, (1844–1925), consort to Edward VII, at the Royal London Hospital, notes that she "introduced to England the Finsen light cure for Lupus, and presented the first lamp to this hospital".
Etymology
The term "lupus" (meaning "wolf" in Latin) to describe an ulcerative skin disease dates to the late thirteenth century, though it was not until the mid-nineteenth that two specific skin diseases were classified as lupus erythematosus and lupus vulgaris. The term may derive from the rapacity and virulence of the disease; a 1590 work described it as "a malignant ulcer quickly consuming the neather parts; ... very hungry like unto a woolfe".[7]
See also
- Miliary tuberculosis
- Tuberculous gumma (metastatic tuberculous abscess or ulceration)
- List of skin conditions
References
- ^ Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. Chapter 74. ISBN 978-1-4160-2999-1.
- ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 335. ISBN 978-0-7216-2921-6.
- ^ a b c d e f g h Dermatology: An Illustrated Colour Text, 3rd ed. Elsevier Health Sciences. 2002. p. 46. ISBN 9780443071409.
- ^ a b c Dermatology - A colour handbook, 2nd ed. Manson Publishing. 2010. p. 216. ISBN 9781840765960.
- ^ Ghorpade, A (27 August 2003). "Lupus vulgaris over a tattoo mark--inoculation tuberculosis". Journal of the European Academy of Dermatology and Venereology. 17 (5): 569–71. doi:10.1046/j.1468-3083.2003.00787.x. PMID 12941097. S2CID 45399120.
- ^ Varadraj, Vasant Pai (2014). "A clinico-histopathological study of lupus vulgaris: A 3 year experience at a tertiary care centre". Indian Dermatol Online J. 5 (4): 461–465. doi:10.4103/2229-5178.142497. PMC 4228641. PMID 25396129.
- ^ "Lupus", Oxford English Dictionary, online second edition. Accessed 2006
External links
- Image at University of Iowa (graphic)
- Image of lupus vulgaris, 1914 from Our Friend, the Sun: Images of Light Therapeutics from the Osler Library Collection, c. 1901-1944. Digital exhibition by the Osler Library of the History of Medicine, McGill University.
This page was last edited on 25 May 2024, at 13:21