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Hypotaurine

From Wikipedia, the free encyclopedia

Hypotaurine
Skeletal formula of Hypotaurine
Ball-and-stick model of the hypotaurine zwitterion
Names
Preferred IUPAC name
2-Aminoethane-1-sulfinic acid
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.155.825 Edit this at Wikidata
KEGG
UNII
  • InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5) checkY
    Key: VVIUBCNYACGLLV-UHFFFAOYSA-N checkY
  • InChI=1/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)
    Key: VVIUBCNYACGLLV-UHFFFAOYAM
  • O=S(O)CCN
Properties
C2H7NO2S
Molar mass 109.15 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Hypotaurine is a sulfinic acid that is an intermediate in the biosynthesis of taurine. Like taurine, it also acts as an endogenous neurotransmitter via action on the glycine receptors.[1] It is an osmolyte with antioxidant properties.[2]

Hypotaurine is derived from cysteine (and homocysteine). In mammals, the biosynthesis of hypotaurine from cysteine occurs in the pancreas. In the cysteine sulfinic acid pathway, cysteine is first oxidized to its sulfinic acid, catalyzed by the enzyme cysteine dioxygenase. Cysteine sulfinic acid, in turn, is decarboxylated by sulfinoalanine decarboxylase to form hypotaurine. Hypotaurine is enzymatically oxidized to yield taurine by hypotaurine dehydrogenase.[3]

Hypotaurine (3) is an intermediate in the conversion of cysteine (1) to taurine (4).

References

  1. ^ Kalir, Asher; Kalir, Henry H. "Biological activity of sulfinic acid derivatives" in Chemistry of Sulphinic Acids, Esters Their Derivatives Edited by Patai, Saul. Wiley, New York, 1990, pp. 665.
  2. ^ Paul H. Yancey (2005). "Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stresses". Journal of Experimental Biology. 208 (15): 2819–2830. doi:10.1242/jeb.01730. PMID 16043587.
  3. ^ Sumizu K (1962). "Oxidation of hypotaurine in rat liver". Biochim. Biophys. Acta. 63: 210–212. doi:10.1016/0006-3002(62)90357-8. PMID 13979247.
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This page was last edited on 2 June 2021, at 02:06
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