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Hepatic fructokinase

From Wikipedia, the free encyclopedia

ketohexokinase (fructokinase)
Ketohexokinase homodimer, Human
Identifiers
SymbolKHK
NCBI gene3795
HGNC6315
OMIM229800
RefSeqNM_006488
UniProtP50053
Other data
EC number2.7.1.3
LocusChr. 2 p23.3-23.2
Search for
StructuresSwiss-model
DomainsInterPro

Hepatic fructokinase (or ketohexokinase) is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate.

ATP +
Fru
   ADP +
F1P
ATP + D-fructose → ADP + D-fructose-1-phosphate[1]

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Transcription

Pathology

A deficiency is associated with essential fructosuria.

References

  1. ^ Bais R, James HM, Rofe AM, Conyers RA (1985). "The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol". Biochem. J. 230 (1): 53–60. doi:10.1042/bj2300053. PMC 1152585. PMID 2996495.

External links


This page was last edited on 23 May 2024, at 16:17
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